NLR、PLR及FIB对慢性阻塞性肺疾病急性加重的诊断价值

Value of NLR,PLR and fibrinogen in diagnosis of AECOPD

目的:探讨中性粒细胞/淋巴细胞(NLR)、血小板/淋巴细胞(PLR)及纤维蛋白原(FIB)对慢性阻塞性肺疾病急性加重(AECOPD)的诊断价值。方法:选择2021年1—9月在我院住院的85例AECOPD患者为试验组,同期门诊复诊的43例稳定期慢性阻塞性肺疾病患者为对照组,均做血常规和凝血指标检测,对其检测结果进行分析。结果:试验组NLR、PLR及FIB明显高于对照组,差异均有统计学意义(P<0.01);NLR与白细胞计数、PLR、FIB均呈正相关(r=0.478、0.644、0.246,P<0.05);NLR、PLR、FIB诊断AECOPD的曲线下面积分别为0.765、0.669、0.662。结论:NLR、PLR及FIB检测可反映机体的炎症反应程度,在AECOPD诊断中有一定的临床价值。

Objective:To investigate the value of neutrophil-to-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR and fibrinogen(FIB)in the diagnosis of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:85patients with AECOPD hospitalized in our hospital from January 2021 to September 2021 were selected as the experimental group,and 43 return visit outpatients with stable chronic obstructive pulmonary disease during the same period were selected as the control group.Blood routine and coagulation indexes were tested,and the results were analyzed.Results:NLR,PLR and FIB in the experimental group were significantly higher than those in the control group(P<0.01);NLR was significantly positively correlated with WBC,PLR and FIB(r=0.478,0.644,0.246,P<0.05);the areas under the curve of NLR,PLR and FIB in the diagnosis of AECOPD were 0.765,0.669 and 0.662,respectively.Conclusion:NLR,PLR and FIB can reflect the degree of inflammatory reaction of the body,and have a certain clinical value in the diagnosis of AECOPD.