妊娠期幽门螺杆菌感染及其与不良妊娠结局的关系

Prevalence of Helicobacter pylori infection during pregnancy and its association with adverse pregnancy outcomes

目的探究妊娠期幽门螺杆菌(Hp)感染及其与不良妊娠结局的关系。方法选取2020年3月-2021年3月在绍兴市柯桥区妇幼保健院行规律产检并分娩的106例伴剧吐的妊娠期妇女为研究对象,统计其妊娠期Hp感染情况、一般资料、妊娠合并症及不良妊娠结局,并分析Hp感染与不良妊娠结局的关系。结果106例妊娠期妇女中,Hp感染发生率44.34%(47/106),不良妊娠结局发生率14.15%(15/106);Hp感染组与Hp未感染组一般资料比较,无统计学差异;Hp感染组妊娠期糖尿病、妊娠期贫血发生率分别为23.40%(11/47)、21.28%(10/47),高于Hp未感染组(P<0.05);Hp感染组不良妊娠总发生率为23.40%(11/47),高于Hp未感染组(P<0.05);Hp感染、妊娠期糖尿病、妊娠期贫血、胎盘异常均为妊娠期妇女出现不良妊娠结局的影响因素(P<0.05);Logistic回归分析结果显示,Hp感染为妊娠期妇女出现不良妊娠结局的危险因素(P<0.05)。结论妊娠期妇女幽门螺旋杆菌感染发生率较高,会增加其不良妊娠结局风险,临床需早发现、早治疗,以改善母婴结局。

OBJECTIVE To explore the prevalence of Helicobacter pylori infection and analyze its association with adverse pregnancy outcomes.METHODS A total of 106 pregnant women complicated with hyperemesis who received routine prenatal examination and gave birth in Keqiao Maternal and Child Health Hospital from Mar 2020 to Mar 2021 were recruited as the study subjects.The prevalence of Hp infection,baseline data,gestational complications and adverse pregnancy outcomes were statistically analyzed,and the association between the Hp infection and the adverse pregnancy outcomes was observed.RESULTS Among the 106 pregnant women,the incidence rate of Hp infection was 44.34%(47/106),the incidence of adverse pregnancy outcomes was 14.15%(15/106).There was no significant difference in the baseline data between the Hp infection group and the no Hp infection group.The incidence rates of gestational diabetes mellitus and gestational anemia of the Hp infection group were 23.40%(11/47)and 21.28%(10/47),significantly higher than those of the no Hp infection group(P<0.05).The total incidence of adverse pregnancy outcomes of the Hp infection group was 23.40%(11/47),significantly higher than that of the no Hp infection group(P<0.05).The Hp infection,gestational diabetes mellitus,gestational anemia and placental abnormalities were the influencing factors for the adverse pregnancy outcomes in the pregnant women(P<0.05).Logistic regression analysis showed that the Hp infection was the risk factor for the adverse pregnancy outcomes in the pregnant women(P<0.05).CONCLUSION The incidence of Hp infection is high among the pregnant women,the Hp infection can increase the risk of adverse pregnant outcomes.It is necessary for the hospital to test in early stage and conduct early treatment so as to improve maternal and infant outcomes.