菌群代谢产物在艰难类梭菌感染中的作用研究进展

Progress of research on microbiome metabolites in Clostridioides difficile infection

艰难类梭菌感染(CDI)已成为危害全球的公共卫生问题,肠道菌群紊乱是其发病的关键因素。肠道菌群与宿主相互作用的主要模式之一是菌群代谢物,即为菌群代谢过程的中间体或最终产物。近年来,越来越多的证据表明菌群代谢物在CDI中起了关键作用,尤其是短链脂肪酸、胆汁酸和色氨酸衍生物。它们通过对菌株本身的影响及其对宿主的潜在作用发挥效应。本文对肠道菌群代谢物和CDI的现有关联研究进行综述,为菌群代谢物防治CDI进一步的研究奠定基础。

Clostridioides(formerly Clostridium) difficile infection(CDI) has become a global public health problem, and the disturbance of gut microbiome is the key factor of its incidence. One of the main modes of interaction between gut microbiome and host is microbial metabolites, small molecules that are produced as intermediate or end products of microbial metabolism. Recently, mounting evidence has suggested a key role for microbiome-derived metabolites in CDI, especially short-chain fatty acids, bile acids and tryptophan derivatives. This includes a significant impact of these metabolites upon C.difficile strain itself directly, along with potential additional benefits on host response. This review provides an updated comprehensive overview of the available evidence in the field of gut microbiome-derived metabolites and CDI, and laid a foundation for further studies on the control of CDI by microbiome metabolites.