IFN-γ基因多态性及术前炎症指标与宫颈癌术后感染的关联

Relationship between IFN-γ gene polymorphism, preoperative inflammatory indexes and postoperative infection in cervical cancer patients

目的 探究干扰素(IFN)-γ基因多态性及术前炎症指标与宫颈癌术后感染的关联。方法 选择2018年10月-2020年10月南阳市中心医院收治的126例宫颈癌患者为研究对象,患者均行手术治疗,比较术后感染组与非感染组患者IFN-γ基因多态性及术前炎症指标水平及其临床意义。结果 126例宫颈癌患者术后感染49例,感染率为38.89%,感染组患者+874T/A位点A等位基因频率及+2109A/G位点G等位基因频率均高于非感染组(P<0.05),感染组患者术前炎症指标IFN-γ、降钙素原(PCT)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平均高于非感染组(P<0.05),IFN-γ基因+874T/A位点AA基因患者炎症指标水平高于TA、TT基因患者(P<0.05),+2109A/G位点GG基因患者炎症指标水平高于AA、AG基因患者(P<0.05)。结论 IFN-γ基因多态性与宫颈癌患者术后感染关系密切,并可能通过调节患者术前炎症因子水平介导患者术后感染的发生。

OBJECTIVE To explore the relationship between interferon(IFN)-γ gene polymorphism, preoperative inflammatory indexes and postoperative infection in cervical cancer patients. METHODS Totally 126 cervical cancer patients who were treated in the Nanyang Central Hospital from Oct 2018 to Oct 2020 were recruited as the study objects, all of the patients received surgical procedures, the IFN-γ gene polymorphism and levels of preoperative inflammatory indexes were compared between the infection group and the no infection group, and the clinical significance was observed. RESULTS Totally 49 of 126 cervical cancer patients had postoperative infection, with the infection rate 38.89%. The frequencies of A allele at +874 T/A locus and G allele at +2109 A/G locus were higher in the infection group than in the no infection group(P<0.05). The levels of preoperative inflammatory indexes IFN-γ, procalcitonin(PCT), C-reactive protein(CRP) and tumor necrosis factor-α(TNF-α) of the infection group were higher than those of the no infection group(P<0.05). The levels of inflammatory indexes of the patients with AA genotype at +874 T/A locus of IFN-γ gene were higher than those of the patients with TA and TT genotypes(P<0.05);the levels of inflammatory indexes of the patients with GG genotype at +2109 A/G locus were higher than those of the patients with AA and AG genotypes(P<0.05). CONCLUSION The IFN-γ gene polymorphism is closely associated with the postoperative infection in the cervical cancer patients, which may mediate the incidence of postoperative infection by regulating the levels of preoperative inflammatory factors.