心肺耦合技术检测惊恐障碍睡眠特征研究

Study on sleep characteristics of patients with panic disorder detected by cardiopulmonary coupling technology

目的利用心肺耦合(cardiopulmonary coupling,CPC)技术检测惊恐障碍患者的睡眠特征。方法纳入2019年9月至2020年6月淮安市第三人民医院门诊或住院的未治疗惊恐障碍(panic disorder,PD)患者31例为患者组,选择年龄、性别匹配的健康对照29名为对照组,利用CPC设备检测睡眠指标。结果与对照组相比,患者组的睡眠总时间[(7.84±1.41)h vs.(6.06±1.30)h]、浅睡时间[2.70(2.30,3.90)h vs.1.90(1.40,2.55)h]、快速眼动睡眠时间[(1.77±0.64)h vs.(1.13±0.44)h]、觉醒时间[0.90(0.60,1.20)h vs.0.40(0.35,0.60)h]增加,睡眠效率降低[89.20%(86.30%,93.00%)vs.92.70%(91.65%,94.25%)],差异有统计学意义(P<0.05)。logistic回归分析显示睡眠总时间(OR=0.32,95%CI:0.17~0.60)、睡眠效率(OR=1.31,95%CI:1.09~1.59)与惊恐障碍相关联。结论CPC检测显示PD患者的睡眠与健康对照存在显著差异,主要表现在睡眠总时间增加,睡眠效率降低。

Objective Cardiopulmonary coupling(CPC)technology was utilized to identify the sleep characteristics of patients with panic disorder(PD).Methods From September 2019 to June 2020,31 patients with PD who were outpatients or hospitalized at the third people’s Hospital of Huai’an city were enrolled in the study.Twenty-nine age-and sex-matched healthy controls were served as the controls.CPC devices were used to detect sleep parameters.Results Compared with the control group,the total sleep time of the patient group[(7.84±1.41)h vs.(6.06±1.30)h],light sleep time[2.70(2.30,3.90)h vs.1.90(1.40,2.55)h],REM sleep time[(1.77±0.64)h vs.(1.13±0.44)h],wake time[0.90(0.60,1.20)h vs.0.40(0.35,0.60)h]increased,but sleep efficiency decreased[89.20%(86.30%,93.00%)vs.92.70%(91.65%,94.25%)],the difference was significant(P<0.05).Logistic regression analysis showed that total sleep time(OR=0.32,95%CI:0.17~0.60)and sleep efficiency(OR=1.31,95%CI:1.09-1.59)were associated with PD.Conclusion The CPC test shows that the sleep quality of PD patients is significantly different from that of healthy controls,which is mainly manifested in the increase of total sleep time and the decrease of sleep efficiency.