滋肾清肝法对妊娠期高血压-子痫前期患者母婴结局、血液高凝状态、微炎症指标的影响

Effects of nourishing kidney and clearing liver method on maternal and infant outcomes,blood hypercoagulability and micro-inflammatory indexes in patients with gestational hypertension and preeclampsia

目的:探究妊娠期高血压-子痫前期(HDP)患者应用滋肾清肝法对母婴结局、血液高凝状态及微炎症指标的影响。方法:选择109例妊娠期高血压-子痫前期患者为对象,采用随机数字表法进行分组,对照组54例采用盐酸拉贝洛尔片治疗,观察组55例加用滋肾清肝法治疗,比较两组患者临床疗效、血液高凝状态、微炎症指标、母婴结局及不良反应。结果:治疗后,观察组患者血小板α-颗粒膜蛋白(GMP-140)及血管性血友病因子(vWF)参数低于对照组,凝血酶原时间(PT)水平高于对照组(P<0.05);观察组肿瘤坏死因子(TNF-α)、超敏C反应蛋白(hs-CRP)及白细胞介素-6(IL-6)水平低于对照组(P<0.05);观察组发生新生儿窒息、胎盘早剥、胎儿生长发育迟缓的比例低于对照组(P<0.05);观察组治疗总有效率为89.09%,对照组总有效率为72.22%,两组疗效比较差异有统计学意义(P<0.05);观察组不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论:滋肾清肝法辅助治疗HDP患者,可明显改善患者血液高凝状态,降低微炎症指标水平,降低发生不良母婴结局的风险,提高临床疗效,且安全性高。

Objective:To study the effect of nourishing kidney and clearing liver method on maternal and infant outcomes,blood hypercoagulability and micro-inflammatory indexes in patients with pregnancy-induced hypertensionpreeclampsia(HDP).Methods:A total of 109 patients with gestational hypertension and preeclampsia were selected in⁃to this study,and they were divided into groups by random number table method.The control group of 54 patients were treated with labetalol hydrochloride tablets,and the observation group of 55 patients were treated by nourishing kidney and clearing liver method.After the treatment,he clinical efficacy,blood hypercoagulability,micro-inflammatory indi⁃cators,maternal and infant outcomes and adverse reactions between the two groups of patients were compared.Results:After treatment,the parameters of plateletα-granule membrane protein(GMP-140)and von Willebrand factor(vWF)in the observation group were lower than those in the control group,and the levels of prothrombin time(PT)were higher than those in the control group(P<0.05);the levels of tumor necrosis factor(TNF-α),high-sensitivity C-reactive pro⁃tein(hs-CRP)and interleukin-6(IL-6)in the observation group were lower than those in the control group(P<0.05).The rates of infant asphyxia,placental abruption,and fetal growth retardation were lower than those in the control group(P<0.05).The total effective rate was 89.09%in the observation group and 72.22%in the control group,and the differ⁃ence between the two groups was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion:The method can signif⁃icantly reduce the hypercoagulable state of the patient's blood,improve the micro-inflammation index,reduce the risk of adverse maternal and infant outcomes,improve the clinical efficacy.It has high safety in the adjuvant treatment of HDP patients.