摘要
Repeated blood transfusions in thalassemia patients is followed by endo-crinopathies as diabetes,hypothyroidism,hypogonadism,hypoparathy-roidism,and disorders in calcium and vitamin D homeostasis.The aim of this study was to evaluate the association of beta-thalassemia patients endocrinopathies and osteoporosis.Serum level of some factors related to the function of gonads,thyroid,adrenal,and pancreas along with serum levels of calcium,phosphate,albumin,vitamin D,and iron were measured.Bone marrow density was tested via dualenergy x-ray absorptiometry(DXA densitometry).In this study,56 patients with major thalassemia were investigated.Paraclinical analysis indicated osteopenia in 17(30.4%)and osteoporosis in 39 patients(69.6%)in addition to other types of endocrine disorders,such as hypogonadism in 29(51.8%),hypothyroidism in 13(23.2%),hypoparathyroidism in 1(1.8%),hypocortisolism in 2(3.6%),and diabetes in 9(16.1%)patients.Endocrinopathies had no signifi cant relationship with osteoporosis and osteopenia in men.However,hypogonadism had a significant relationship with osteoporosis and osteopenia in women with thalassemia.Estradiol level was lower in women with osteoporosis in comparison with women with osteopenia.Ferritin levels had neither association with osteoporosis nor with LH levels(P>0.05).Secondary hypogonadism disorders are the main causes of osteoporosis and osteopenia in female beta-thalassemia patients.
