阴道镜联合LEEP术治疗宫颈癌前病变的临床疗效分析

Analysis of the clinical efficacy of colposcopy combined with LEEP in the treatment of cervical precancerous lesions

目的 探讨宫颈癌前病变应用阴道镜联合宫颈环形电切术(LEEP术)治疗的临床效果。方法 98例宫颈癌前病变患者,根据治疗方法不同分为对照组及观察组,各49例。对照组应用宫颈激光烧灼治疗,观察组应用阴道镜联合LEEP术治疗。比较两组的治疗效果、手术相关指标、宫颈塑形满意度及术后1年复发率。结果 观察组患者手术时间(21.01±3.50)min、术后阴道出血时间(8.40±1.31)d及住院时间(10.72±1.56)d明显短于对照组的(38.17±5.60)min、(12.12±2.21)d、(15.03±1.96)d,术中出血量(16.02±2.70)ml少于对照组的(22.79±5.30)ml,差异具有统计学意义(P<0.05)。观察组治疗总有效率95.9%明显高于对照组的79.6%,差异具有统计学意义(P<0.05)。观察组宫颈塑形满意度93.9%明显高于对照组的73.5%,差异具有统计学意义(P<0.05)。观察组患者术后1年疾病复发率4.1%明显低于对照组的16.3%,差异具有统计学意义(P<0.05)。结论 阴道镜联合LEEP术治疗宫颈癌前病变具有优越性,可减少术中损伤,利于患者康复,并能降低复发率,提升患者治疗满意度,建议临床应用。

Objective To discuss the clinical effect of colposcopy combined with loop electrosurgical excision procedure(LEEP) in the treatment of cervical precancerous lesions. Methods A total of 98 patients with cervical precancerous lesions were divided into control group and observation group according to different treatment methods, with 49 cases in each group. The control group was treated with cervical laser cauterization,and the observation group was treated with colposcopy combined with LEEP. Both groups were compared in terms of therapeutic effect, surgery-related indicators, satisfaction with cervical shaping and 1-year recurrence rate after surgery. Results The operation time(21.01±3.50) min, postoperative vaginal bleeding duration(8.40±1.31) d and hospitalization time(10.72±1.56) d in the observation group were significantly shorter than(38.17±5.60) min,(12.12±2.21) d,(15.03±1.96) d in the control group, and the intraoperative blood loss(16.02±2.70) ml was less than(22.79±5.30) ml in the control group. All the differences were statistically significant(P<0.05). The total effective rate of treatment in the observation group was 95.9%, which was significantly higher than 79.6%in the control group, and the difference was statistically significant(P<0.05). The satisfaction rate of cervical shaping in the observation group was 93.9%, which was significantly higher than 73.5% in the control group, and the difference was statistically significant(P<0.05). The recurrence rate at 1 year after surgery in the observation group was 4.1%, which was significantly lower than 16.3% in the control group, and the difference was statistically significant(P<0.05). Conclusion Colposcopy combined with LEEP has advantages in the treatment of cervical precancerous lesions, and can reduce intraoperative injury, conducive to patient rehabilitation, reduce the recurrence rate, and improve the satisfaction of patients, which is suggested for clinical application.