双歧杆菌活菌与蒙脱石散联合治疗小儿腹泻的近期疗效观察

Observation on the short-term efficacy of Bifidobacterium viable bacteria combined with montmorillonite powder in the treatment of diarrhea in children

目的 探讨小儿腹泻采用双歧杆菌活菌与蒙脱石散联合治疗的近期疗效。方法 100例小儿腹泻患儿,随机分为观察组与对照组,各50例。对照组采取常规补液、纠正水电解质及蒙脱石散治疗,观察组在对照组基础上应用双歧杆菌活菌治疗。比较两组患儿相关临床指标、临床疗效、不良事件发生情况、炎性因子水平、患儿家长满意度。结果 观察组患儿用药治疗后止泻时间(18.05±2.26)h、退热时间(40.28±3.22)h、止吐时间(16.52±2.28)h、大便恢复正常时间(52.09±4.33)h、脱水纠正时间(49.21±5.32)h均短于对照组的(26.85±3.25)、(53.85±4.28)、(23.58±3.25)、(71.08±8.22)、(65.82±5.31)h,差异均具有统计学意义(P<0.05)。观察组患儿临床总有效率96.00%高于对照组的80.00%,差异具有统计学意义(P<0.05)。观察组不良事件发生率4.00%低于对照组的16.00%,患儿家长总满意度98.00%高于对照组的82.00%,差异均具有统计学意义(P<0.05)。观察组患儿白细胞介素(IL)-6(8.24±3.74)pg/ml、IL-17(9.09±2.56)pg/ml均低于对照组(12.26±4.26)、(13.45±3.55)pg/ml,分泌型免疫球蛋白A(IgA)(142.68±24.89)μg/ml高于对照组的(105.98±12.55)μg/ml,差异均具有统计学意义(P<0.05)。结论 小儿腹泻治疗中,采用双歧杆菌活菌与蒙脱石散药物治疗,能显著提高疗效,缩短临床症状改善时间,降低患儿不良事件发生率。

Objective To discuss the short-term efficacy of Bifidobacterium viable bacteria combined with montmorillonite powder in the treatment of infantile diarrhea. Methods A total of 100 children with diarrhea were randomly divided into observation group and control group, with 50 cases in each group. The control group was treated with conventional fluid infusion, correction of water-electrolytes and montmorillonite powder, and the observation group was treated with Bifidobacterium viable bacteria on the basis of the control group. The clinical indicators, clinical efficacy, complications, levels of inflammatory factors, and parental satisfaction were compared between the two groups. Results After drug treatment, the antidiarrheal time(18.05±2.26) h,antipyretic time(40.28±3.22) h, antiemetic time(16.52±2.28) h, recovery time of stool property(52.09±4.33) h,dehydration correction time(49.21±5.32) h in the observation group were shorter than(26.85±3.25),(53.85±4.28),(23.58±3.25),(71.08±8.22),(65.82±5.31) h in the control group, and the differences were statistically significant(P<0.05). The total clinical effective rate in the observation group was 96.00%, which was higher than 80.00% in the control group, and the difference was statistically significant(P<0.05). The complication rate 4.00% in the observation group was lower than 16.00% in the control group, and the parental satisfaction 98.00% was higher than 82.00% in the control group. All the differences were statistically significant(P<0.05).The interleukin(IL)-6(8.24±3.74) pg/ml and IL-17(9.09±2.56) pg/ml in the observation group were lower than(12.26±4.26) and(13.45±3.55) pg/ml in the control group, and the immunoglobulin A(IgA)(142.68±24.89) μg/ml was higher than(105.98±12.55) μg/ml of the control group. All the differences were statistically significant(P<0.05). Conclusion The combination of Bifidobacterium viable bacteria and montmorillonite powder in the treatment of diarrhea in children can significantly improve the clinical efficacy, shorten the improvement time of clinical symptoms, and reduce the incidence of adverse events in children.