阿昔洛韦联合小儿豉翘清热颗粒及重组人干扰素α2b喷雾剂治疗小儿疱疹性瘭疽的疗效及安全性探讨

Efficacy and safety of acyclovir combined with Xiao’er Chiqiao Qingre granules and recombinant human interferon α2b spray in the treatment of children with herpetic whitlow

目的 观察阿昔洛韦(ACV)联合小儿豉翘清热颗粒及重组人干扰素α2b喷雾剂治疗小儿疱疹性瘭疽的临床疗效和安全性。方法 67例疱疹性瘭疽患儿,经随机数字表法分成对照组(32例)和观察组(35例)。对照组应用阿昔洛韦和重组人干扰素α2b喷雾剂治疗,观察组在对照组基础上加用小儿豉翘清热颗粒治疗。比较两组治疗效果、不良反应发生情况及复发情况。结果 观察组治疗痊愈16例,显效19例,有效0例,无效0例,治疗总有效率为100.00%;对照组治疗痊愈7例,显效16例,有效9例,无效0例,治疗总有效率为71.88%。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。两组肝肾功能、尿常规均未发生明显变化,未发现有肝肾功能损害情况发生。两组均未出现复发情况。结论 阿昔洛韦联合小儿豉翘清热颗粒及重组人干扰素α2b喷雾剂治疗儿童疱疹性瘭疽疗效显著,能快速控制病情,且未发现不良反应,安全性良好。

Objective To observe the clinical efficacy and safety of acyclovir(ACB) combined with Xiaoer Chiqiao Qingre granules and recombinant human interferon α2b spray in the treatment of children with herpetic gangrene. Methods A total of 67 children with herpetic whitlow were divided into control group(32 cases) and observation group(35 cases) by random numerical table. The control group was treated with acyclovir and recombinant human interferon α2b spray, and the observation group was additionally treated with Xiaoer Chiqiao Qingre granules on the basis of the control group. The therapeutic effect, occurrence of adverse reactions and recurrence were compared between the two groups. Results In the observation group, 16 cases were cured, 19 cases were markedly effective, 0 case was effective, and 0 case was ineffective, and the total effective rate was 100.00%;in the control group, 7 cases were cured, 16 cases were markedly effective, 9 cases were effective,and 0 case was ineffective, and the total effective rate was 71.88%. The total effective rate in the observation group was higher than that in the control group, and the difference was statistically significant(P<0.05). There were no statistically significant changes in liver and kidney function and routine urine test in the two groups, and no liver and kidney function damage was found. No recurrence occurred in both groups. Conclusion Acyclovir combined with Xiao’er Chiqiao Qingre granules and recombinant human interferon α2b spray has a remarkable efficacy in the treatment of children with herpetic whitlow, and can quickly control the disease, with no adverse reactions and high safety.