2387例儿童青少年骨龄调查分析

Investigation and analysis of bone age of 2387 children and adolescents

目的调查分析娄底市中心医院2387例儿童青少年的骨龄情况,为该地区骨龄评估提供参考。方法运用TW骨龄评分法中TW3法对2387例儿童青少年的左手腕部骨龄进行评价,其中身高、体重、体质量指数(BMI)百分位数值均在P_(3)~P_(97)范围内的正常儿童青少年1610例(67.45%),应用Pearson直线相关分析正常儿童青少年骨龄与生活年龄的相关性,比较不同性别、身高、BMI儿童青少年的骨龄与生活年龄差值。结果Pearson直线相关分析显示,儿童青少年的骨龄与生活年龄呈显著正相关(r=0.918,P=0.000<0.05),其中男性、女性儿童青少年的骨龄与生活年龄均呈显著正相关(r=0.933、0.899,P=0.000<0.05)。1610例正常儿童青少年:男性中,3~11岁共9个年龄段,骨龄均小于生活年龄,差异有统计学意义(P<0.05)。女性中,5~6岁2个年龄段骨龄小于生活年龄,11~13岁3个年龄段骨龄大于生活年龄,差异有统计学意义(P<0.05)。男、女骨龄正常比例相当,分别为458例(51.81%)和383例(52.75%),而骨龄提前女性占比24.52%(178/726)高于男性的13.35%(118/884),差异有统计学意义(P<0.05)。2387例儿童青少年:身高<P_(3)男性儿童青少年检出率为21.62%(280/1295),高于女性的13.64%(149/1092),差异有统计学意义(P<0.05)。身高<P_(3)男、女性骨龄分别落后生活年龄(1.50±1.13)、(1.18±1.07)岁、1.18岁,BMI<P_(3)的男、女性骨龄分别落后生活年龄(1.36±1.02)、(1.00±0.99)岁。结论男性儿童青少年在大部分年龄段骨龄小于生活年龄,女性较男性骨龄提前,矮身材或BMI<P_(3)的儿童青少年易发生骨龄落后。

Objective ObjectiveTo investigate and analyze the bone age of 2387 children and adolescents in Loudi Central Hospital,so as to provide a reference for the evaluation of bone age in this region.Methods The bone age of the left wrist of 2387 children and adolescents was evaluated with TW3 method of TW bone age scoring method.Among them,1610 normal children and adolescents(67.45%)whose height,weight and body mass index(BMI)percentile values were within the range of P_(3)-P_(97) were analyzed by applying Pearson linear correlation analysis to correlate normal children and adolescents'bone age with their chronological age,and to compare the difference between bone age and chronological age of children and adolescents with different gender,height and BMI..The bone age development levels in children of different gender,height and body mass index(BMI)were also compared.Results Pearson linear correlation analysis showed that the bone age of the children and adolescents in our hospital was significantly positively correlated with the chronological age(r=0.918,P=0.000<0.05),and the bone age of the male and female children and adolescents was significantly positively correlated with the chronological age(r=0.933,0.899,P=0.000<0.05).In 1610 normal children and adolescents,for males,in all 9 age groups from 3 to 11 years old,the bone age was younger than the chronological age,and the difference was statistically significant(P<0.05).For females,in 2 age groups(i.e.5-6 years old),the bone age was younger than the chronological age.In 3 age groups(i.e.11-13 years old),the bone age was older than the chronological age,and the difference was statistically significant(P<0.05).In the present study,the proportion of normal bone age was similar for males and females,i.e.458 cases(51.81%)and 383 cases(52.75%),respectively.The proportion of early bone age in females was 24.52%(178/726),which was higher than 13.35%(118/884)in males,and the difference was statistically significant(P<0.05).In 2387 children and adolescents,the detection rate of male children and adolescents with height<P3 was 21.62%(280/1295),which was higher than 13.64%(149/1092)of female children,and the difference was statistically significant(P<0.05).The bone age of males with height<P3 was(1.50±1.13)years younger than the chronological age,while the bone age of females with height<P3 was(1.18±1.07)years younger than the chronological age.The bone age of males with BMI<P3 was(1.36±1.02)years younger than the chronological age,while the bone age of females with BMI<P_(3) was(1.00±0.99)year younger than the chronological age.Conclusion For male children and adolescents,the bone age is younger than the chronological age in most age groups.The bone age of females is younger than that of males.Children and adolescents with low height or BMI<P_(3) are prone to retardation of bone age.