2型糖尿病患者与干眼症的相关性及其影响因素分析

Correlation of type 2 diabetes and dry eye and its influencing factors analysis

目的 探讨分析2型糖尿病患者与干眼症的相关性及其影响因素。方法 选取2019年10月至2021年2月在首都医科大学附属北京友谊医院眼科门诊就诊的2型糖尿病患者43例(86眼)为研究组,非糖尿病患者43例86眼为对照组进行前瞻性研究。比较两组患者的干眼症发病率、空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、泪液破裂时间、以及泪液分泌试验与角膜荧光素染色结果,并对研究组患者中可能影响干眼症发生的一些因素进行多因素Logistic回归分析。结果 研究组的干眼症发病率为(65. 12%,56/86),显著高于对照组(18. 60%,16/86),差异有统计学意义(P<0.05)。研究组的泪液破裂时间为(6. 15±3. 27) s,显著短于对照组[(12. 96±3. 61) s],泪液分泌试验滤纸润湿长度为(8. 21±3. 85) mm,显著短于对照组[(12. 03±1. 95) mm],角膜荧光素染色评分为(2. 01±1. 52)分,明显高于对照组(0. 61±0. 23)分,差异均有统计学意义(P<0.05)。研究组的FBG、Hb A1c为(10. 13±4. 91) mmol/L、(9. 05±3. 21)%,均明显高于对照组[(5. 12±2. 03) mmol/L、(5. 31±1. 93)%],差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示:年龄、糖尿病病程、泪液破裂时间和Hb A1c均为2型糖尿病患者发生干眼症的危险因素。结论 2型糖尿病患者是干眼症的易患人群,临床中应针对影响干眼症发病的因素进行防范。

Objective To investigate the relationship between type 2 diabetes and dry eye and its influencing factors.Methods A total of 43 patients(86 eyes)with type 2 diabetes who visited the Eye Clinic of Beijing Friendship Hospital,Capital Medical University from October 2019 to February 2021 were selected as the research group,and 43 patients(86 eyes)without diabetes were selected as the control group for prospective study.The incidence of dry eye,fasting blood glucose(FBG),hemoglobin A1c(HbA1c),tear break-up time,schirmerI test and corneal fluorescein staining test were compared between the two groups,and multivariate logistic regression analysis was performed.Results The incidence of dry eye in the study group was(65.12%,56/86),which was significantly higher than that in the control group(18.60%,16/86),the difference was statistical significance(P<0.05).The tear break-up time of the study group was(6.15±3.27)s,which was significantly shorter than that of the control group[(12.96±3.61)s],and the filter paper wetting length of the tear secretion test was(8.21±3.85)mm,which was significantly shorter than that of the control group[(12.03±1.95)mm],the corneal fluorescein staining score was(2.01±1.52)pionts,which was significantly higher than that of the control group(0.61±0.23)pionts,and the differences were statistically significant(P<0.05).The FBG and HbA1c of the study group were(10.13±4.91)mmol/L,(9.05±3.21)%,which were significantly higher than those of the control group[(5.12±2.03)mmol/L,(5.31±1.93)%],the differences were statistical significance(P<0.05).Multivariate Logistic regression analysis showed that age,duration of diabetes,tear breakup time and HbA1c were all risk factors for dry eye in patients with type 2 diabetes.Conclusion Type 2 diabetes is a susceptible population for dry eye.In clinical practice,preventive measures should be taken against the influencing factors of the pathogenesis of dry eye.