动静脉畸形动物模型的研究及应用进展

Research and application progress of animal models for arteriovenous malformation

动静脉畸形(Arteriovenous malformations,AVM)是一类较少见且高风险的血管畸形。尽管目前血管内治疗、手术治疗及联合治疗已应用于该疾病的治疗,但风险较高,且效果不一。近几十年来,已有多种实验模型被用于AVM发病机制、血流动力学变化、组织学等的研究,以期加深对该疾病的认识,从而探索更有效的治疗手段。但目前仍缺乏能完美模拟人体各种动静脉畸形的动物模型。本文对近年来AVM相关动物模型的研究及其应用的优缺点进行综述。

Arteriovenous malformations(AVM) is a relatively rare and high risk vascular malformations. Although endovascular therapy, surgical therapy and combined therapy have been used in clinical practice, there are still many difficulties and challenges in the diagnosis and treatment of this disorder. In recent decades, a variety of experimental models have been developed to study the pathogenesis, hemodynamic changes and histology of AVM, so as to deepen the understanding of the disease and achieve better therapeutic effects. These models have their own advantages and disadvantages, but there is still a lack of animal models that can perfectly simulate various AVM in humans. In this paper,the recent research on AVM related animal models and their advantages and disadvantages in application were all reviewed.