红细胞分布宽度/白蛋白比值在急性中毒患者中的应用研究

Application of Red Blood Cell Distribution Width/albumin Ratio in Patients with Acute Poisoning

目的:探讨红细胞分布宽度(Red Cell Distribution Width,RDW)/白蛋白(Albumin)比值(RAR)在急性中毒患者病情评估中的应用价值。方法:检测100例我院收治的中毒患者作为实验组,30例我院健康体检职工作为对照组,比较两组RAR值。将中毒患者依据30内生存或死亡分为生存组和死亡组,比较两组RAR值、急性生理学及慢性健康状况评分系统评分(APACHEⅡ评分)。比较RAR值与APACHEⅡ评分的相关性。采用ROC曲线比较RAR与APACHEⅡ评分在急性中毒患者病情预后中的作用。结果:实验组的RAR明显高于对照组(P<0.05)。实验组中死亡组的RAR与APACHEⅡ评分均高于生存组(P<0.05)。(3)RAR与APACHEⅡ评分呈正相关(r=0.596,P<0.05),绘制RAR和APACHEⅡ评分对急性中毒疾病预后的ROC曲线,显示RAR的AUC为0.805,95%可信区间为(0.68-0.93),截断值为4,825,敏感度为0.850,特异度为0.733。APACHEⅡ评分的AUC为0.784,95%可信区间为(0.66-0.91),截断值为26.5,敏感度为0.785,特异度为0.712。结论:急性中毒患者的RAR值上升,检测RAR值对患者的预后评估有一定的价值。

Objective:To investigate the application value of Red Cell Distribution Width(RDW)/Albumin ratio(RAR)in the evaluation of acute poisoning patients.Methods:100 poisoned patients admitted to our hospital were tested as experimental group,and 30 health examination workers in our hospital were used as control group to compare the RAR values of the two groups. The poisoned patients were divided into survival and death groups based on survival or death within 30 days,and the RAR values,acute physiology and chronic health status scores(APACHE Ⅱ score)were compared between the two groups Points. Correlations of RAR values with APACHE Ⅱ scores were compared. ROC curves were used to compare the role of RAR and APACHE Ⅱ score in the prognosis of patients with acute poisoning.Results:There was no significant difference in age and gender between the experimental group and the control group(P>0.05),RAR in experimental group was significantly higher than that in control group(P<0.01)RAR and APACHEⅡscores in death group were higher than those in survival group(P<0.01),there was no significant difference in age between the two groups(P>0.05). RAR was positively correlated with APACHE score(r=0.596,P<0.05),the ROC curve of RAR and APACHE Ⅱscore on the prognosis of acute poisoning disease was drawn,which showed that the AUC of RAR was 0.805,95% confidence interval was 0.68 to 0.93,cut-off value was 4,825,sensitivity was 0.850,and specificity was 0.733.The AUC of APACHE Ⅱ was 0.784,95% confidence interval was 0.66-0.91,cut-off value was 26.5,sensitivity was 0.785,and specificity was 0.712.Conclusion:The RAR value of patients with acute poisoning increased,and the detection of RAR value has certain value for the prognosis evaluation of patients.