瑜伽对乳腺癌患者癌因性疲乏影响的Meta分析

Meta-analysis of the effect of yoga on cancer-related fatigue in breast cancer patients

目的评价瑜伽对乳腺癌患者癌因性疲乏(CRF)的影响。方法2名研究者对中国知网、万方数据库及中国维普全文数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Embase、Cochrane Library、Web of Science进行检索,检索时间为建库至2021年12月29日。纳入瑜伽对乳腺癌患者CRF影响的随机对照试验(RCT)研究。采用Cochrane 5.1.0版偏倚风险工具进行文献质量评估。RevMan 5.4.1软件进行Meta分析。结果最终纳入13项研究,共810例患者。Meta分析结果显示,瑜伽能缓解乳腺癌患者CRF[SMD=-0.47,95%CI(-0.71,-0.24),P<0.0001]。亚组分析显示,30~75 min单次瑜伽干预时间、每周瑜伽干预时间≥1.5 h、瑜伽干预周期为6周、总瑜伽干预时间≥18 h、侧重于体式和呼吸的瑜伽干预训练、团体瑜伽干预和个体瑜伽干预均可缓解乳腺癌患者CRF症状。结论瑜伽可改善乳腺癌患者CRF。

Objective To evaluate the effect of yoga on cancer-related fatigue(CRF)in breast cancer patients.Methods We arranged 2 researchers to search China National Knowledge Infrastructure,Wanfang data,VIP,China Biomedical Literature Service Database(CBM),PubMed,Embase,Cochrane Library and Web of science,and the search time was from the establishment of the database to December 29,2021.A randomized controlled trial(RCT)study of the effect of yoga on CRF in breast cancer patients was included.The quality of the literature was assessed using the Cochrane risk of bias tool,version 5.1.0.Meta-analysis was performed with RevMan 5.4.1software.Results Thirteen studies with a total of 810 patients were finally included.The result of Meta-analysis showed that the yoga relieves CRF in breast cancer patients[SMD=-0.47,95%CI(-0.71,-0.24),P<0.0001].Subgroup analysis showed that 30-75 min single yoga intervention time,weekly yoga intervention time≥1.5 h,yoga intervention period of 6 weeks,total yoga intervention time≥18 h,yoga intervention training focusing on asana and breathing,group yoga intervention and individual yoga intervention can alleviate CRF symptoms in breast cancer patients.Conclusion Yoga can improve CRF in breast cancer patients.