miR-142-3p、miR-216a、miR-107-5p在ICU血液净化AKI患者中的表达及对疗效的评估价值分析

The expression of miR-142-3p,miR-216a and miR-107-5p in AKI patients undergoing blood purification in ICU and their evaluation value for therapeutic effect

目的分析miR-142-3p、miR-216a、miR-107-5p在ICU血液净化急性肾损伤(acute kidney injury,AKI)患者中的表达及对疗效的评估价值。方法选取我院ICU收治的行血液净化治疗的AKI患者132例作为AKI组,同期选取于我院行健康体检的健康志愿者80例作为健康组。检测miR-142-3p、miR-216a、miR-107-5p表达量,分析其在ICU血液净化AKI患者中的表达,所有患者均行血液净化治疗,对比患者治疗前后及不同疗效下上述指标表达量,分析三者对疗效的评估价值。结果与健康组相比,AKI组miR-142-3p、miR-107-5p表达升高,miR-216a表达降低(P<0.05)。与治疗前相比,治疗后AKI组患者miR-142-3p、miR-107-5p表达升高,miR-216a表达降低(P<0.05)。根据治疗是否有效分为治疗有效组110例,治疗无效组22例。与治疗有效组相比,miR-142-3p、miR-107-5p在治疗无效组表达升高,miR-216a在治疗无效组中表达降低(P<0.05)。与存活患者相比,miR-142-3p、miR-107-5p在死亡患者中表达升高,miR-216a在死亡患者中表达降低,差异有统计学意义(P<0.05)。ROC曲线分析显示,miR-142-3p、miR-216a、miR-107-5p对ICU血液净化AKI患者疗效的评估价值均较高(P<0.05)。结论ICU血液净化AKI患者miR-142-3p、miR-107-5p高表达,miR-216a低表达,且与临床疗效密切相关,可用于患者疗效的评估。

Objective To analyze the expression of miR-142-3p,miR-216a and miR-107-5p in patients with acute kidney injury(AKI)undergoing blood purification in ICU and their value of efficacy evaluation.Methods A total of 132 AKI patients who received blood purification treatment in ICU of our hospital were selected as the AKI group,and 80 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the healthy group.The expression levels of miR-142-3p,miR-216a and miR-107-5p were detected and analyzed in AKI patients undergoing blood purification in ICU.All patients received blood purification therapy.The expression levels of the above indexes before and after treatment and under different therapeutic effects were compared to analyze the efficacy evaluation value of the three indexes.Results Compared with those the healthy group,the expressions of miR-142-3p and miR-107-5p were increased,while the expression of miR-216a was decreased in the AKI group(P<0.05).Compared with those before treatment,the expressions of miR-142-3p and miR-107-5p were increased,while the expression of miR-216a was decreased in AKI group after treatment(P<0.05).According to therapeutic effect,they were divided into the effective treatment group(n=110)and the ineffective treatment group(n=22).Compared with the effective treatment group,the expressions of miR-142-3p and miR-107-5p were increased in the ineffective treatment group,while the expression of miR-216a was decreased in the ineffective treatment group(P<0.05).Compared with surviving patients,miR-142-3p and miR-107-5p were elevated,while miR-216a was decreased in dead patients,and the difference was statistically significant(P<0.05).ROC curve analysis showed that miR-142-3p,miR-216a and miR-107-5p all had a high value in evaluating the efficacy of blood purification in ICU for AKI patients(P<0.05).Conclusion The high expression of miR-142-3p and miR-107-5p and low expression of miR-216a in AKI patients undergoing blood purification in ICU are closely related to clinical efficacy and can be used to evaluate the efficacy of patients.