骨质疏松症与心理应激关系的研究进展

Research update on osteoporosis and psychological stress

骨质疏松症和慢性心理应激是致残并影响人口健康的两种严重慢性退行性疾病。骨质疏松症患者往往表现出较高的心理负担, 生活质量下降, 抑郁和焦虑症状频发。这些疾病之间存在潜在的共同致病因素、细胞机制和信号通路。考虑到这两种疾病患者基数庞大, 并且还在快速增长, 因此研究两者在发病机制上的联系, 寻找对骨骼和心理健康都有利的治疗尤为重要, 尤其是对并发骨质疏松症和心理健康障碍的高危患者。

Osteoporosis and chronic psychological stress are two serious chronic degenerative diseases that cause disability and impact population health.Patients with osteoporosis often present with heavier psychological burden,lower quality of life,and frequent symptoms of depression and anxiety.There are potential common pathogenic factors,cellular mechanisms and signaling pathways between them.Considering that the number of patient with these diseases is huge and growing rapidly,it is particularly important to explore the pathogenic link between these two diseases as well as cross-effect therapeutics for osteoporosis and mental health disorders.