^(18)F-前列腺特异性膜抗原-1007 PET/CT鉴别正常神经节与前列腺癌淋巴结转移

^(18)F-prostate specific membrane antigen-1007 PET/CT for differentiating normal ganglia and lymph node metastasis of prostate cancer

目的观察^(18)F-前列腺特异性膜抗原(PSMA)-1007 PET/CT鉴别正常神经节与前列腺癌淋巴结转移的价值。方法回顾性分析80例接受早期及延迟期^(18)F-PSMA-1007 PET/CT检查的前列腺癌患者,观察星状神经节、腹腔神经节及骶神经节的显示率,以及其与全身转移性淋巴结最大标准摄取值(SUV_(max))和ΔSUV_(max)(延迟期SUV_(max)-早期SUV_(max))的差异,评估PET/CT鉴别二者的价值。结果80例中,60例(75.00%,60/80)PET/CT至少显示1个星状神经节/腹腔神经节/骶神经节;PET/CT对于腹腔神经节、星状神经节及骶神经节的显示率分别为66.25%(53/80)、56.25%(45/80)及30.00%(24/80),差异有统计学意义(χ^(2)=22.44,P<0.001)。星状神经节/腹腔神经节/骶神经节的早期、延迟期SUV_(max)及ΔSUV_(max)均显著低于转移性淋巴结(P均<0.001)。神经节与淋巴结的ΔSUV_(max)构成比差异有统计学意义(P<0.001);神经节SUV_(max)多较稳定,淋巴结延迟期SUV_(max)多高于早期SUV_(max)。结论^(18)F-PSMA-1007 PET/CT有助于根据解剖位置及SUV_(max)鉴别正常神经节与前列腺癌淋巴结转移。

Objective To observe the value of^(18)F-prostate specific membrane antigen(PSMA)-1007 PET/CT for differentiating normal ganglia and lymph node metastasis of prostate cancer.Methods Data of 80 patients with prostate cancer who underwent early and delayed^(18)F-PSMA-1007 PET/CT examinations were retrospectively analyzed.The display rates of stellate ganglion,celiac ganglion and sacral ganglion were observed,and the maximum standard uptake value(SUV_(max))andΔSUV_(max)(SUV_(max) in delayed phase-SUV_(max) in early phase)were compared between ganglia and systemic metastatic lymph nodes,hence the differential value of PET/CT was analyzed.Results Among 80 prostate cancer patients,PET/CT showed at least 1 ganglion(stellate/celiac/sacral)in 60 patients(75.00%,60/80).The display rate of PET/CT of celiac ganglion,stellate ganglion and sacral ganglion was 66.25%(53/80),56.25%(45/80)and 30.00%(24/80),respectively,with significant differences(χ^(2)=22.44,P<0.001).SUV_(max) in early and delayed phase andΔSUV_(max) of stellate/celiac/sacral ganglion were all significantly lower than those of metastatic lymph nodes(all P<0.001),and there was significant difference of the constituent ratio ofΔSUV_(max) between ganglion and lymph node(P<0.001).SUV_(max) of ganglions were rather stable,while of lymph node in delayed phase was higher than in early phase.Conclusion According to anatomical location and SUV_(max),^(18)F-PSMA-1007 PET/CT was helpful for differentiating normal ganglia and lymph node metastasis of prostate cancer.