中医药调控哮喘Th17/Treg细胞失衡的研究进展

Research Progress of Traditional Chinese Medicine Regulating Th17/Treg Cell Imbalance in Asthma

辅助性T细胞17(Helper T cells Th17,Th17)和调节性T细胞(Tregulatory cell,Treg)都是经初始CD_(4)^(+)T细胞分化而来,同属于CD_(4)^(+)T细胞亚群的范畴。在感染性疾病、自身免疫性疾病、肿瘤等疾病中发挥免疫调节的作用。支气管哮喘是由多种细胞及细胞组分参与的气道慢性炎症性疾病。近些年来,越来越多的动物实验和临床试验的研究表明,Th17/Treg平衡与哮喘的发生、发展、程度及预后的关系密切。通过查阅近年来相关文献,对Th17细胞及Treg细胞的分化、功能、两者平衡以及中医中药的调节等加以阐述。

Helper T cells(Th17)and regulatory T cells(Treg)are derived from primary CD_(4)^(+)T cells and belong to the category of CD_(4)^(+)T cell subsets.It plays an important role in immune regulation in infectious diseases,autoimmune diseases,tumors and other diseases.Bronchial asthma is a chronic inflammatory disease of airway,which involves many kinds of cells and cell components.In recent years,more and more animal and clinical studies have shown that Th17/Treg balance is closely related to the occurrence,development,degree and prognosis of asthma.In this paper,the differentiation,function,balance of Th17 cells and Treg cells,and the regulation of traditional Chinese medicine were discussed by consulting the relevant literature in recent years.