五味子醇甲对中枢神经系统药理作用研究进展

Research Progress on Pharmacological Effects of Schisandrin on Central Nervous System

五味子醇甲作为中药五味子的主要活性成分之一,也是鉴别南北五味子的重要物质之一。在各个系统具有广泛的药理作用,尤其在中枢神经系统的作用最为显著,具有对神经退行性疾病(阿尔茨海默症、帕金森病)潜在的预防和治疗作用、调节改善睡眠作用、抗抑郁作用以及对脑缺血的保护作用等。综合近年来诸多文献资料对五味子醇甲在中枢神经系统药理作用及机制研究进行总结,为有望进一步开发成为单体药物提供理论依据。

Schisandrin is the main active ingredient of Wuweizi(Fructus Schisandrae Chinensis)in traditional Chinese medicine,and it is also one of the important substances for identifying the northern Wuweizi(Fructus Schisandrae Chinensis)and southern Wuweizi(Fructus Schisandrae Sphenantherae).It has a wide range of pharmacological effects in various systems,especially in the central nervous system.It has a potential role in the prevention and treatment of neurodegenerative diseases(Alzheimer’s disease,Parkinson’s disease),regulating and improving sleep,anti-depression and the protection of cerebral ischemia,etc.This article summarized many literatures in recent years to summarize the pharmacological effects and mechanisms of schizandrin in the central nervous system and provide a theoretical basis for the further development of a single drug.