治疗炎症性肠病的纳米颗粒研究进展

Research progress on nanoparticles in treatment of inflammatory bowel disease

炎症性肠病是一组慢性非特异性肠道炎症性疾病,目前临床上常用的传统非靶向药物可以缓解患者症状,但不能终止黏膜炎症活动、疾病发展,且严重的不良反应限制了这些药物的应用。纳米颗粒由于其独特的大小和物理特性,能够通过黏液层将负载药物传递到肠道细胞,也可以通过内吞作用被巨噬细胞吞噬,从而调节肠道的免疫环境,此外,纳米颗粒还具有改变药物特性的潜力。总结了治疗炎症性肠病的合成纳米颗粒、天然纳米颗粒的研究情况,以期为炎症性肠病的治疗带来新的机遇。

Inflammatory bowel disease is a group of chronic non-specific intestinal inflammatory diseases.Traditional non-targeted drugs commonly used in clinic can relieve the symptoms of patients,but cannot stop mucosal inflammatory activities and disease development,and serious adverse reactions limit applications of these drugs.Due to its unique size and physical properties,nanoparticles can deliver loaded drugs to intestinal cells through the mucus layer,and can also be phagocytosed by macrophages through endocytosis to regulate the immune environment of the intestine.In addition,nanoparticles also have the potential to alter drug properties.This paper summarizes the research progress on synthetic nanoparticles and natural nanoparticles for the treatment of inflammatory bowel disease,hoping to bring new opportunities for the treatment of inflammatory bowel disease.