乳腺癌患者动态增强MRI时间-信号强度曲线与肿瘤细胞生物学行为的相关性

Correlation between the Dynamic Contrast-Enhanced MRI Time-signal Intensity Curve and the Biological Behavior of Tumor Cells in Breast Cancer Patients

探究乳腺癌患者动态增强MRI时间-信号强度曲线与肿瘤细胞生物学行为的相关性。选取60例乳腺癌患者作为观察组,另选取同期收治的60例乳腺良性病变患者作为对照组,均进行动态增强MRI检查。结果显示,观察组对比剂最大浓度(Max Cone)、时间-信号强度曲线的曲线下面积(AUC)、时间-信号强度曲线的最大斜率(Max Slop)、速率常数(Kep)、转运常数(Ktrans)、血浆容积分数(Vp)高于对照组,达峰时间(TTP)低于对照组(P<0.05);Ktrans、Kep、Vp、TTP、Max Cone、Max Slop、AUC联合诊断乳腺癌的AUC为0.913;观察组CXCL1、Notch1、Gab2、FOXF1 mRNA表达量高于对照组,ATG2B、ATG4D mRNA表达量低于对照组(P<0.05);乳腺癌患者动态增强MRI时间-信号强度曲线参数Ktrans、Kep、Vp、Max Cone、Max Slop、AUC与CXCL1、Notch1、Gab2、FOXF1 mRNA表达量呈正相关关系,与ATG2B、ATG4D mRNA表达量呈负相关关系(P<0.05);TTP与CXCL1、Notch1、Gab2、FOXF1 mRNA表达量呈负相关关系,与ATG2B、ATG4D mRNA表达量呈正相关关系(P<0.05)。乳腺癌患者动态增强MRI时间-信号强度曲线参数变化与肿瘤细胞生物学行为密切相关。

This study explored the correlation between the dynamic enhanced MRI time-signal intensity curve and the biological behavior of tumor cells in breast cancer patients.60patients with breast cancer were selected as the observation group,and 60patients admitted to the same period with benign breast lesions were selected as the control group.All patients underwent dynamic enhanced MRI examination.The results showed that the maximum concentration of contrast agent(Max Cone),area under timesignal intensity curve(AUC),time-signal intensity curve maximum slope(Max Slop),rate constant(Kep),transport constant(Ktrans),plasma volume fraction(Vp)in the observation group were higher than those in the control group,while the time to peak (TTP)was lower than that in the control group(P<0.05).The AUC of Ktrans,Kep,Vp,TTP,Max Cone,Max Slop and(time-signal intensity curve)AUC in the combined diagnosis of breast cancer were 0.913.The mRNA expression levels of CXCL1,Notch1,Gab2 and FOXF1in observation group were higher than those in the control group,while the expressions of ATG2Band ATG4D were lower than the control group(P<0.05).The dynamic contrast-enhanced MRI time-signal intensity curve parameters of Ktrans,Kep,Vp,Max Cone,Max Slop,AUC was positively correlated with the mRNA expression of CXCL1,Notch1,Gab2,FOXF1,while negatively correlated with ATG2B,ATG4D mRNA expression (P<0.05).TTP was negatively correlated with CXCL1,Notch1,Gab2,FOXF1 mRNA expression,and was positively correlated with ATG2B,ATG4D mRNA expression(P<0.05).The parameter changes of dynamic enhanced MRI time-signal intensity curve in breast cancer patients are closely related to the biological behavior of tumor cells.