超声联合血清OPN、IL-1β诊断乳腺癌骨转移的研究

Study of Ultrasound Combined with Serum OPN and IL-1β in the Diagnosis of Breast Cancer Bone Metastasis

本文探讨超声(US)联合血清骨桥蛋白(OPN)、白细胞介素-1β(IL-1β)在乳腺癌骨转移中的诊断价值。对60例乳腺癌患者进行了US检查,并通过酶联免疫吸附分析法(ELISA)测定患者血清OPN和IL-1β水平。结果显示,US诊断骨转移的敏感性为82.35%,特异性为80.77%。与未骨转移的患者相比,骨转移患者血清OPN和IL-1β水平均显著升高(P<0.001)。与US阴性组的患者相比,US阳性组患者血清OPN和IL-1β水平均显著升高(P<0.001)。随着US分级的升高,血清OPN和IL-1β水平均逐渐升高(P<0.05)。OPN诊断骨转移的敏感性为52.94%,特异性为96.15%。IL-1β诊断骨转移的敏感性为82.35%,特异性为84.62%。OPN和IL-1β联合诊断骨转移的敏感性为79.41%,特异性为80.77%。US、OPN和IL-1β在诊断乳腺癌骨转移中均具有不同的作用,其中,US和IL-1β的敏感性更高,OPN的特异性更高,联合更有利于乳腺癌骨转移的早期诊断。

This study investigated the diagnostic value of ultrasound(US) combined with serum osteopontin(OPN) and interleukin-1β(IL-1β) in breast cancer bone metastasis. 60 breast cancer patients were examined by US, and the serum OPN and IL-1β levels were measured by enzyme-linked immunosorbent assay(ELISA). The results showed that the sensitivity of US in diagnosing bone metastases was 82.35% and the specificity was 80.77%. Compared with patients without bone metastases, the serum OPN and IL-1β levels in patients with bone metastases were significantly higher(P<0.001). Compared with patients in the US negative group, the levels of serum OPN and IL-1β in the US positive group were significantly increased(P<0.001). The serum OPN and IL-1β levels gradually increased with the increase of US grade(P<0.05). The sensitivity and specificity of OPN were 52.94% and 96.15% in the diagnosis of bone metastases, respectively. The sensitivity of IL-1β in diagnosing bone metastasis was 82.35% and the specificity was 84.62%. The sensitivity of OPN combined with IL-1β in the diagnosis of bone metastasis was 79.41%, and the specificity was 80.77%. US, OPN and IL-1β all play different roles in the diagnosis of breast cancer bone metastases, among which US and IL-1β have a higher sensitivity and OPN has a higher specificity, and the combination is more conducive to the early diagnosis of breast cancer bone metastases.