透明质酸钠复合溶液联合肉毒毒素治疗口周皱纹的效果

Effects of injectable compound solution of hyaluronic acid combined with botulinum toxin on perioral wrinkles

目的探讨注射用透明质酸钠复合溶液联合肉毒毒素治疗口周皱纹的效果。方法2018年1月至2020年12月,中国医学科学院整形外科医院体型雕塑与脂肪移植中心治疗口周皱纹女性患者60例,年龄45~60(53±5)岁。将透明质酸钠复合溶液(2.5 ml/支)及肉毒毒素均匀注射至白唇真皮层。根据需要分别将透明质酸钠复合溶液(1.5 ml/支、嗨体熊猫针)注射至静态皱纹及唇缘白唇的真皮内。治疗后3~6个月随访,拍照记录治疗前后情况,由2名医师评估治疗前后皱纹严重程度,并评估患者满意度。结果口周皱纹严重程度评分治疗后显著下降(P<0.001);60例患者对治疗结果满意,45例(75%)患者非常满意,15例(25%)患者基本满意。60例患者术后出现轻度肿胀,于1~5 d缓解;9例(15%)患者出现局部瘀斑,于7~10 d缓解;未见其他并发症。结论注射用透明质酸钠复合溶液联合肉毒毒素治疗口周皱纹是一种安全有效的方法。

Objective To evaluate the efficacy and safety of injectable compound solution of hyaluronic acid combined with botulinum toxin in the treatment of perioral wrinkles.Methods A total of 60 female patients,aged 45-60(53±5)years,with perioral wrinkles treated by the above mentioned method in Plastic Surgery Hospital,CAMS,PUMC from January 2018 to December 2020 were reviewed.Injectable compound solution of hyaluronic acid(2.5 ml)and botulinum toxin were injected intradermally into the upper and lower lips.Injectable compound solutions of hyaluronic acid(1.5 ml and Hearty Xiongmaozhen)were injected intradermally in the perioral static wrinkles and the lip border,respectively,as needed.The patients were followed up for 3 to 6 months after treatment.Photographs were taken before the treatment and during the follow-up visits.The pre-and post-treatment severity of perioral wrinkles were evaluated by two independent surgeons.Patients′satisfaction was evaluated.Results All the 60 patients were included.The severity of perioral wrinkles was significantly reduced after the treatments.All the patients were satisfied with the results.Among them,45 patients(75%)were very satisfied and 15 patients(25%)were satisfied with the results.Mild swelling occurred in all patients and was relieved in 1-5 days.Mild bruising was observed in 9 patients(15%)and was relieved in 7-10 days.No other complications were documented.Conclusions Injectable compound solution of hyaluronic acid combined with botulinum toxin is a safe and effective method in the treatment of perioral wrinkles.