高分辨质谱技术在中药分析中的研究进展

Research Progress on Application of High-resolution Mass Spectrometry in Analysis of Traditional Chinese Medicines

中药分析涉及中药物质基础研究、药物代谢、中药质量控制等多个领域,是中药现代化研究的基础。随着现代化分析技术的发展,中药分析研究取得了极大的进展。针对中药成分复杂、代谢过程多样、目标物浓度低等难点,高分辨质谱技术凭借精确质量数、高分辨率及高灵敏度的优点在中药分析中具有显著优势。该文对高分辨质谱技术在中药分析中的应用进行了综述,重点介绍了四极杆飞行时间质谱、静电场轨道阱质谱、傅里叶变换离子回旋共振质谱和离子淌度串联质谱等质谱技术的发展,以及高分辨质谱在中药化学成分鉴定、中药化合物代谢研究、中药植物代谢组学研究以及中药有害化学成分检测中的研究进展。同时,对高分辨质谱在中药分析中的应用进行了展望,以期促进中药现代化发展。

The analysis of traditional Chinese medicine(TCM)involves many fields such as material basis research,drug metabolism and quality control,which is the basis for the modernization of TCM.With the development of modern analytical technology,great progress has been made in the study of TCM.In view of the difficulties of complex components,diverse metabolic processes and low concentration of analytes,the advantages of high-resolution mass spectrometry technology such as accurate mass number,high resolution and high sensitivity have obvious predominance in TCM analysis.This review summarizes the progress on mass spectrometry,including quadrupole time of flight mass spectrometry,orbitrap mass spectrometry,Fourier transform ion cyclotron resonance mass spectrometry and ion mobility spectrometry,as well as the application of high resolution mass spectrometry in the analysis of TCM,including chemical components identification,compound metabolism,plant metabolomics of TCM and harmful chemical components analyzing.Meanwhile,the application prospect of high resolution mass spectrometry is also discussed.It is hopeful to promote the modernization of traditional Chinese medicine.