维持性血液透析患者血清gas6蛋白与腹主动脉钙化相关性分析

Correlation between serum gas6 protein and abdominal aortic calcification in maintenance hemodialysis patients

目的:探究维持性血液透析患者体内的gas6蛋白水平与腹主动脉钙化的关系。方法:选择行维持性血液透析的患者62例为试验组行腹部侧位片,根据Kauppila半定量积分法对其腹主动脉钙化程度进行评分,根据评分结果分为四组,即无钙化组、轻度钙化组、中度钙化组及重度钙化组,随机选择同期体检的健康人群29例作为对照组,收集所有入组对象的临床资料,试验组于检测前白蛋白(PA)、血钙(Ca)、血磷(P)、血脂、甲状旁腺激素(iPTH)等生化指标,并使用酶联免疫吸附试验(ELISA)检测血清gas6蛋白水平,分析各组的血清gas6蛋白水平与腹主动脉钙化程度的关系。结果:(1)与健康对照组相比,血液透析患者的血清gas6蛋白水平明显升高(P=0.004<0.05);(2)62例血液透析患者的平均年龄为(61.39±13.77)岁,平均透析龄为(43.36±38.12)个月,其中50例血液透析患者的腹主动脉发生钙化(80.6%);(3)在四个试验组间腹主动脉钙化严重程度与年龄、碱性磷酸酶(ALP)、iPTH、透析龄呈正相关,与PA、收缩压、舒张压、总胆固醇(TC)、低密度脂蛋白(LDL)呈负相关;(4)四个试验组血清gas6蛋白水平差异有统计学意义(H=9.383,P=0.025<0.05),使用Spearman进行统计分析后提示血液透析患者的血清gas6蛋白水平和腹主动脉钙化的严重程度呈正相关。结论:血液透析患者的腹主动脉钙化发病率较高,其体内血清gas6蛋白水平与其腹主动脉钙化程度呈正相关。

Objective To explore the relationship between gas6 protein level and abdominal aortic calcification in maintenance hemodialysis patients.Method 62 patients who underwent maintenance hemodialysis were selected as the experimental group.The degree of abdominal aortic calcification was scored according to kauppila semi quantitative integral method. According to the scoring results, they were divided into four groups: no calcification group, mild calcification group, moderate calcification group and severe calcification group.29 healthy people who underwent physical examination in hospital in the same period were randomly selected as the control group, The clinical data of all subjects were collected. The biochemical indexes such as prealbumin, blood calcium, blood phosphorus, blood lipid and iPTH were detected in the experimental group, and the serum gas6 protein level was detected by ELISA. The difference of gas6 protein level between the experimental group and the control group was evaluated by comparing the serum gas6 protein level between the experimental group and the control group, The relationship between the level of serum gas6 protein and the degree of abdominal aortic calcification was analyzed.Results(1) Compared with the healthy control group, the level of serum gas6 protein in hemodialysis patients was significantly higher(P=0.004<0.05);(2) The average age of 62 hemodialysis patients was(61.39±13.77) years and the average dialysis age was(43.36±38.12) months. Among them, 50 hemodialysis patients had abdominal aortic calcification(80.6%);(3)Among the four experimental groups, the severity of abdominal aortic calcification was positively correlated with age, alkaline phosphatase, parathyroid hormone and dialysis age, and negatively correlated with prealbumin, systolic blood pressure, diastolic blood pressure, total cholesterol and low density lipoprotein;(4) There was significant difference in serum gas6 protein level among the four experimental groups(H=9.383,P=0.025<0.05). Spearman statistical analysis showed that the serum gas6 protein level of hemodialysis patients was positively correlated with the severity of abdominal aortic calcification.Conclusion The incidence rate of abdominal aortic calcification in hemodialysis patients is high. The serum gas6 protein level is positively correlated with the degree of abdominal aortic calcification. We believe that serum gas6 protein is a risk factor for abdominal aortic calcification, which is of great significance in predicting the severity of abdominal aortic calcification in hemodialysis patients.