1,3-二氢-3-亚烷基-吲哚-2-酮的膦催化合成研究

Phosphine-Catalyzed Synthesis of 1,3-Dihydro-3-alkylidene-2H-indol-2-ones

报道了一类三(4-甲氧基苯基)膦催化联烯酰亚胺与吲哚-2-酮之间的迈克尔加成/双键移位串联反应.该反应条件温和,操作简单,产物收率较高,具有较好的底物适应性和化学选择性,为1,3-二氢-3-亚烷基-吲哚-2-酮骨架的构建提供了一种有效的新方法,最后,还提出了可能的反应历程.

A P(4-OMe-CH)-catalyzed Michael addition/double bond migration tandem reaction between allenyl imide and indol-2-ones was developed.This synthetic strategy for diverse 1,3-dihydro-3-alkylidene-2 H-indol-2-ones features operationally simple,good substrate scope,high chemoselectivity and mild reaction conditions.The proposed reaction mechanism is also provided.