摘要
从栗色鼠尾草全草的乙醇提取物中分离得到一个新的吉马烷型倍半萜内酯类化合物salviatanolide A(1).化合物1的结构通过一维/二维NMR和HRESIMS波谱分析技术得到确认.通过X-ray单晶衍射实验还确认了化合物1的绝对构型.利用人源化秀丽隐杆线虫的阿尔兹海默症病理模型,筛选了化合物1的抗阿尔兹海默症活性.生物活性结果表明,化合物1能显著地延缓秀丽隐杆线虫麻痹表型的阿尔兹海默症症状,提示该化合物可作为抗阿尔兹海默症的候选化合物.
One new germacrane-type sesquiterpene lactone,named as salviatanolide A(1)was isolated from an ethanol extract of the whole plant of Salvia castanea.Its structure was elucidated by 1D and 2D-NMR and HRESIMS spectra,and its absolute configuration was determined by single crystal X-ray crystallography.The anti-Alzheimer’s disease(AD)activity of 1 was evaluated using humanized Caenorhabditis elegans AD pathological model.Compound 1 significantly delayed AD-like symptoms of worm paralysis phenotype,which may be potential to be served as anti-AD agent candidate.
作者
刘绪
苏盼杰
崔文博
张宗萍
陈晓涵
王儒月
费冬青
张占欣
Liu Xu;Su Panjie;Cui Wenbo;Zhang Zongping;Chen Xiaohan;Wang Ruyue;Fei Dongqing;Zhang Zhanxin(School of Pharmacy and State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2022年第7期2243-2247,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.31670350,31870324)
甘肃省自然科学基金(Nos.21JR7RA444,21JR7RA477)资助项目.
关键词
栗色鼠尾草
吉马烷型倍半萜内酯
抗阿尔兹海默症活性
秀丽隐杆线虫
Salvia castanea
germacrane-type sesquiterpene lactone
anti-Alzheimer’s disease activity
Caenorhabditis elegans
