广西地区67 990例体检人群甲状腺结节检出情况及危险因素分析

Analysis of detection and risk factors of thyroid nodule in 67990 health physical examination population in Guangxi

目的了解广西地区健康体检人群甲状腺结节的患病情况及相关危险因素,为甲状腺结节的防治提供理论依据。方法选取在健康管理中心进行体检的67990名受检者为研究对象,按年龄分层及性别统计甲状腺结节的患病率,采用单因素和多因素logistic回归分析甲状腺结节的危险因素。结果67990名受检者,甲状腺结节的检出率为44.3%,其中男性和女性检出率分别为38.1%、53.4%,各年龄组检出率女性均大于男性,差异有统计学意义(P<0.001)。随着年龄的增长甲状腺结节患病率呈逐渐升高趋势(P<0.001)。单因素分析提示性别(女性)、高龄、肥胖、高血压及高尿酸血症均为甲状腺结节的风险因素(P<0.01),多因素logistic回归分析结果仅提示女性、高龄、肥胖及高血压为甲状腺结节的高危因素(P<0.01),而高尿酸血症不是甲状腺结节的独立危险因素(P>0.05)。结论广西地区体检人群甲状腺结节患病率较高,女性、高龄、肥胖、高血压是甲状腺结节发病的独立危险因素,高尿酸血症与甲状腺结节的发生无直接相关。对甲状腺结节高危人群应加强筛查及推行积极的健康管理方案。

Objective To investigate the incidence and risk factors of thyroid nodules in healthy people in Guangxi,and to provide theoretical basis for the prevention and treatment of thyroid nodules.Methods A total of 67,990 subjects who underwent physical examination in the Health Management Center of the People′s Hospital of Guangxi Zhuang Autonomous Region from January 2020 to December 2020 were selected.The prevalence of thyroid nodules was analyzed by age and gender,and the risk factors of thyroid nodules were analyzed by univariate and multivariate logistic regression.Results Among 67,990 subjects,the detection rate of thyroid nodules was 44.3%,and 38.1%in male and 53.4%in female.The detection rates of female were significantly higher than those of male in all age groups(P<0.01).The prevalence of thyroid nodule was significantly increased with age(P<0.01).Univariate analysis showed that gender(female),advanced age,obesity,hypertension and hyperuricemia were all risk factors for thyroid nodule(P<0.01).Multivariate logistic regression analysis showed that female,advanced age,obesity and hypertension were significantly independent risk factors for thyroid nodule(P<0.01).Conclusion The prevalence of thyroid nodules is high in the physical examination population in Guangxi.Female,advanced age,obesity and hypertension are independent risk factors for thyroid nodules.Screening of thyroid nodules in high-risk population should be strengthened and active health management should be implemented.