慢性失眠相关认知损害患者血液生物学标志物研究进展

Research advances in blood biomarkers in patients with chronic insomnia-related cognitive impairment

慢性失眠(CI)是认知损害的重要危险因素,常与认知损害相互作用,导致痴呆的发生。鉴于CI相关认知损害的发病机制目前尚不十分明确,其诊断需要生物学标志物,而血液标本采集的简便、易行性,使血液生物学标志物更易用于临床。现就CI相关认知损害的发生机制、血液生物学标志物研究现状以及星形胶质细胞在CI相关认知损害中的作用前景进行综述,旨在为临床干预CI相关认知损害提供新的思路。

Chronic insomnia(CI)is an important risk factor for cognitive impairment and often interacts with cognitive impairment to promote the development of dementia.Since the pathogenesis of CI-related cognitive impairment remains unclear and biomarkers are required for diagnosis,simple and convenient collection of blood samples makes it easier to use blood biomarkers in clinical practice.This article reviews the pathogenesis of CI-related cognitive impairment,the current status of research on blood biomarkers,and the role of astrocytes in CI-related cognitive impairment,so as to provide new ideas for clinical intervention of CI-related cognitive impairment.