雌激素在高血压及靶器官损害性别差异中的作用

Role of Estrogen in Gender Differences in Hypertension and Target Organ Damage

高血压是心血管疾病的重要危险因素之一,其患病率呈逐年增加趋势。多项研究显示高血压及其靶器官损害存在性别差异,雌激素在其中发挥着重要作用。雌激素可能通过肾素-血管紧张素-醛固酮系统、交感神经系统、肥胖、氧化应激和内皮功能等多种机制影响血压水平以及靶器官功能。

Hypertension is one of the important risk factors of cardiovascular disease, and its prevalence is increasing year by year.A lots of studies have shown that there are gender differences in hypertension and target organ damage, and estrogen plays an important role in them.Estrogen may influence blood pressure and target organ function through a variety of mechanisms, including renin-angiotensin-aldosterone system, sympathetic nerves, obesity, oxidative stress and endothelial function.