酒精性肝病患者肠道微生态变化研究进展

Intestinal microecology in patients with alcoholic liver diseases

目的酒精性肝病(ALD)是全球肝脏疾病相关死亡的重要原因之一,已经成为全球范围内的卫生健康负担。越来越多的证据证明饮酒、肠道微生物失调和肝脏疾病之间存在密切的联系,肠道屏障破坏导致细菌及其产物的移位是关键的致病因素。近年来,通过对饮酒、肠道微生态与ALD进展之间相互作用的研究越来越多,寻找新的生物标志物和治疗靶点也成为预防和治疗ALD的热点。

Objective Alcoholic liver disease(ALD)is one of the major causes of death related to liver disease over the world.The alcohol consumption and the related diseases have become a global health burden.There is growing evidence of strong correlation of intestinal microbiome disorders to liver diseases.The translocation of bacteria and their products caused by the destruction of the intestinal barrier is the key factor to lead to complications of liver diseases.In recent years,many new biomarkers and therapeutic targets are the hotspots in the field of ALD studies.