摘要
尽管医学水平飞速进步,但伤口细菌感染仍严重威胁着人类健康。抗菌水凝胶具有广谱抗菌活性、优异的生物相容性和亲水性,并且抗菌水凝胶的结构与天然细胞外基质相似,已被作为一种有效减轻伤口细菌感染的治疗手段广泛应用于伤口愈合。根据水凝胶的抗菌机理,综述了自身具有抗菌活性的水凝胶、装载抗菌剂的水凝胶及刺激响应型抗菌水凝胶在伤口敷料中的应用研究进展。
Despite the rapid advancement of human medicine,wound bacterial infection is still one of the serious threats to human health.The antibacterial hydrogel has broad-spectrum antibacterial activity,excellent biocompatibility and hydrophilicity.The structure of the hydrogel is similar to that of natural extracellular matrix.It has been widely used in the field of wound healing as effective treatment for alleviating wound bacterial infections.According to the different antibacterial mechanisms of hydrogels,reviewed the research progress of inherent antimicrobial hydrogels,hydrogels loaded with antibacterial agents,and stimuli-response type antibacterial hydrogels.The application prospects of the hydrogels in the biomedical field of wound dressings were look forwarded.
作者
杨航
熊玉竹
兰显玉
王倩
Yang Hang;Xiong Yuzhu;Lan Xianyu;Wang Qian(College of Materials and Metallurgy,Guizhou University,Guiyang 550025;Guizhou Province Engineering Laboratory for Rubber Composites,Guiyang 550025)
出处
《化工新型材料》
CAS
CSCD
北大核心
2022年第8期267-272,共6页
New Chemical Materials
基金
国家自然科学基金(52063006)
贵州省科技计划项目([2019]2166)
贵州省交通运输厅科技项目(2019-112-016)。
关键词
水凝胶
抗菌活性
伤口敷料
生物相容性
hydrogel
antibacterial activity
wound dressing
biocompatibility
