朗格汉斯细胞在银屑病中的作用研究进展

Roles of Langerhans cells in psoriasis

朗格汉斯细胞(LC)是表皮内重要的免疫细胞,具有抗原提呈功能,在炎症状态下经过成熟、活化后,迁移至局部淋巴结并活化初始T细胞,启动免疫应答。近年对LC在银屑病发病中的研究显示,LC具有促进炎症和抑制炎症的双重作用。对LC起源的研究显示,LC有两个亚群,分别具有促炎和抑炎作用,参与不同的免疫应答过程,可能与银屑病免疫异常有关。本文综述LC在银屑病中的研究进展。

Langerhans cells(LC)are important immune cells with antigen-presenting functions in the epidermis.After maturation and activation in an inflammatory state,LC can migrate to local lymph nodes and activate initial T cells to initiate the immune response.Recent studies on the role of LC in pathogenesis of psoriasis have shown that LC play both pro-and anti-inflammatory roles.Studies on the origin of LC have shown that two subsets of LC exert pro-and anti-inflammatory effects respectively,and participate in different immune response processes,which may be related to immune abnormalities in psoriasis.This review systematically elaborates research advances in the role of LC in psoriasis.