喹硫平致低体温的病例分析及文献复习

Case Analysis and Literature Review of Hypothermia Caused by Quetiapine

目的 提高医务人员对喹硫平引起低体温的认识,为防治该不良反应提供参考。方法 回顾性分析1例因服用喹硫平引起低体温病例的临床表现、诊治经过和药物不良反应因果关系,并结合相关文献复习加以讨论。结果 该患者出现低体温很可能与使用喹硫平有关。抗精神病药引发低体温的主要危险因素包括高龄、合用苯二氮?类药物、亚临床甲状腺功能减退、低温环境暴露等。结论 喹硫平引起患者低体温虽不常见,医务人员仍应加强防范。

OBJECTIVE To improve the medical staff’s understanding of the hypothermia caused by quetiapine and to provide reference for the prevention and treatment of the adverse reaction.METHODS The clinical manifestations,diagnosis,treatment and causality of adverse drug reactions in a case of hypothermia caused by quetiapine were retrospectively analyzed and discussed in combination with related literature review.RESULTS Hypothermia in this patient might be related to the use of quetiapine,and the main risk factors of hypothermia caused by antipsychotics include advanced age,combination of benzodiazepines,subclinical hypothyroidism,hypothermic exposure and so on.CONCLUSION Although hypothermia caused by quetiapine is not common,the prevention should be strengthen by medical staff.