耳聋胶囊联合长春西汀对突发性聋患者听力功能、血液流变学及T淋巴细胞亚群的影响

Effects of deafness capsule combined with vinpocetine injection on hearing function,hemorheology and T lymphocyte subsets in patients with sudden deafness

目的探讨耳聋胶囊联合长春西汀注射液对突发性聋患者听力功能、血液流变学及T淋巴细胞亚群的影响。方法选取温州市中心医院2017年4月至2019年10月收治的突发性聋患者80例,采用随机数字表法分为对照组、观察组各40例,对照组采用长春西汀注射液治疗,观察组采用耳聋胶囊联合长春西汀注射液治疗,两组疗程1个月。比较两组疗效、听力功能、血液流变学、T淋巴细胞亚群及不良反应。结果观察组总有效率为90.00%(36/40),高于对照组的67.50%(27/40)(χ^(2)=6.05,P=0.014)。两组不良反应发生率差异无统计学意义(P > 0.05)。治疗1个月后,观察组血浆黏度、全血高切黏度、全血低切黏度分别为(1.21±0.29)mPa·s、(2.41±0.31)mPa·s、(5.25±1.29)mPa·s,均低于对照组的(1.65±0.22)mPa·s、(4.94±0.36)mPa·s、(8.64±1.32)mPa·s(t=7.64、33.68、11.61,均P < 0.001);观察组CD8+、CD4+、CD4+/CD8+分别为(24.28±2.16)%、(46.05±6.52)%、(1.90±0.28),对照组分别为(27.41±2.09)%、(40.54±5.48)%、(1.48±0.24),两组差异均有统计学意义(t=6.58、4.09、7.20,均P < 0.001);观察组纯音听阈值为(38.07±4.82)dB,低于对照组的(51.97±5.96)dB(t=11.46,P < 0.001)。结论耳聋胶囊联合长春西汀注射液治疗突发性聋,可有效改善患者听力功能、血液流变学及T淋巴细胞亚群的免疫功能,疗效肯定。

Objective To investigate the effects of deafness capsule combined with vinpocetine injection on hearing function,hemorheology and T lymphocyte subsets in patients with sudden deafness.Methods Eighty patients with sudden deafness who received treatment in Wenzhou Central Hospital from April 2017 to October 2019 were included in this study.They were randomly assigned to undergo treatment either with vinpocetine injection(control group,n=40)or with deafness capsule combined with vinpocetine injection(observation group,n=40)for 1 month.Efficacy,hearing function,hemorheology,T lymphocyte subsets and adverse reactions were compared between the control and observation groups.Results Total response rate in the observation group was significantly higher than that in the control group[90.00%(36/40)vs.67.50%(27/40),χ^(2)=6.050,P=0.014).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 1 month of treatment,plasma viscosity,high-shear whole blood viscosity,low-shear whole blood viscosity in the observation group were(1.21±0.29)mPa·s,(2.41±0.31)mPa·s,(5.25±1.29)mPa·s respectively,which were significantly lower than those in the control group[(1.65±0.22)mPa·s,(4.94±0.36)mPa·s,(8.64±1.32)mPa·s,t=7.64,33.68,11.61,all P<0.001).The percentages of CD8+,CD4+,and CD4+/CD8+T lymphocyte subsets in the observation group were(24.28±2.16)%,(46.05±6.52)%and(1.90±0.28)respectively,and they were(27.41±2.09)%,(40.54±5.48)%,(1.48±0.24)respectively in the control group(t=6.58,4.09,7.20,all P<0.001).Pure tone threshold in the observation group was significantly lower than that in the control group[(38.07±4.82)dB vs.(51.97±5.96)dB,t=11.46,P<0.001).Conclusion Deafness capsule combined with vinpocetine injection is highly effective on sudden deafness.The combined therapy can improve the hearing function,hemorheology,and the immunological function of T lymphocyte subsets in patients with sudden deafness.