原发性卵巢伯基特淋巴瘤研究进展

Research advance in primary ovarian Burkitt lymphoma

在全部的非霍奇金淋巴瘤(NHL)中,原发性卵巢伯基特淋巴瘤(POBL)是一种罕见的疾病。肿瘤可发生于单侧或双侧卵巢,引起的主要症状为腹痛或较大型腹部包块。依靠影像学特点及组织病理检查对疾病进行鉴别诊断,是进一步治疗不同来源的卵巢肿瘤的基础。尽管大多数卵巢伯基特淋巴瘤患者在发现卵巢肿物后经历了手术治疗,但是对他们而言,治疗的主要方法应是化疗而非进一步的手术。如果化疗方案更积极并联合后续的预防中枢神经系统化疗,预后多较好。现在,多种治疗方案已经被采用,大大提高了患者的存活率。本文通过对文献检索可查到的相关病例,回顾性介绍了POBL的流行病学、临床表现、诊断和治疗。目的是为了在卵巢肿瘤的鉴别诊断中引起临床医生注意POBL发生的可能性。

Among all non-Hodgkin's lymphoma,primary ovarian Burkitt lymphoma(POBL)is a rare disease.Tumors can occur in one or both ovaries.The main symptoms of POBL are abdominal pain or a large abdominal mass.The differential diagnosis of POBL based on imaging characteristics and histopathological examination is the basis for further treatment of ovarian tumors from different sources.Although most patients with POBL have undergone surgical treatment after the discovery of ovarian masses,chemotherapy rather than surgery should be the main treatment method for them.Active chemotherapy combined with preventive central nervous system therapy leads to good prognosis.A variety of treatment schemes have been adopted,which greatly increase the survival rate of patients with POBL.In this review,we retrieved related literature and retrospectively reviewed the epidemiology,clinical manifestation,diagnosis and treatment of POBL.The purpose of this review is to draw clinicians'attention to the possibility of POBL when performing differential diagnosis of ovarian tumors.