药物基因组学检测指导老年精准用药的现状与展望

Pharmacogenomic testing-based precision medicine in the elderly:Current status and prospects

共病问题不可避免地导致老年患者用药数量和不良反应事件增加,因此,在老年人群中实施精准用药迫在眉睫。药物基因检测能够为老年患者增加个体化用药选择的机会,降低药物不良反应的发生风险,降低用药成本效益比,提高用药依从性,降低再入院率。因此,有必要在共病和多重用药的老年患者中推广应用药物基因检测,为老年人个体化用药问题提供解决方案。

Comorbidities will inevitably lead to an increase in the number of medications used and adverse drug reaction events in elderly patients.Therefore,it is urgent to implement precision medicine in the elderly population.pharmacogenomic testing can increase the opportunity of individualized drug selection for elderly patients,reduce the risk of adverse drug reactions,reduce the cost-effectiveness ratio of medication,improve elderly patients'medication compliance,and thus reduce their readmission rate.Therefore,it is necessary to promote pharmacogenetic testing for elderly patients with comorbidities and polypharmacy,so as to provide measures for the implementation of personalized medicine in the elderly.