儿童激素敏感型肾病综合征治疗进展

Progress of the treatment of steroid sensitive nephrotic syndrome in children

原发性肾病综合征是儿童常见肾脏疾病,80%~90%的患儿对糖皮质激素治疗敏感,为激素敏感型肾病综合征。绝大多数患儿初次缓解后会复发,50%~70%表现为频复发或激素依赖。在预防复发的同时尽可能减少药物不良反应是主要治疗目标。现就激素敏感型肾病综合征治疗进展进行综述,为临床制定个体化方案提供参考。

Primary nephrotic syndrome(NS)is a common kidney disease in children.Around 80%to 90%of children with NS are sensitive to corticosteroid treatment.Most of the children with NS will relapse after the first remission,and 50%to 70%of them will develop frequent relapse or steroid dependence.The main target of treatment is to prevent relapse while minimizing the adverse effects of medications.The progress of the treatment of steroid sensitive NS is reviewed in order to provide evidence for individualized therapy.