框架诱导组装策略研究进展

Recent Advancements in Frame-guided Assembly

近年来,两亲分子自组装在生物医药和材料科学领域受到愈加广泛的关注和研究.为了实现特定大小和形态的功能纳米结构的制备,研究者们先后发展了多种稳健的构筑方法.框架诱导组装策略作为一种新兴的有效构筑策略,在精确形貌和尺寸可控的三维纳米囊泡和二维纳米膜方面都取得了一系列重要的研究成果.本文总结并评了述了框架诱导组装策略近十年来的重要研究进展,并展望了该策略在未来存在的挑战和应用前景.

Self-assembly of amphiphiles has attracted more and more attention in the fields of biomedicine and materials science during the last decade.For preparing functional nanostructures with specific size and morphology,researchers have developed a variety of robust construction methods,including film hydration,co solvent,dialysis,microfluidic technologies as well as well frame-guided assembly method,etc.Since the traditional methods have already been well-summarized in detail in many references,therefore,only the construction mechanism and features of these strategies will be addressed here.As a new and effective construction strategy,frame-induced assembly has achieved a series of important achievements in fabrication of three dimensional nanovesicles and two dimensional nanomembranes with precise control on their morphology and size.Based on this novel method,various scaffolds and leading hydrophobic groups have been proven adaptable to form customized nanostructures.In this review,the important research progress of frame-induced assembly strategy in recent ten years will be summarized and evaluated,and the challenges and application prospects of this strategy in the future will be also forecasted.