急性短暂性精神病性障碍患者血清非酶类抗氧化物水平研究

Serum non-enzymatic antioxidant levels in patients with acute and transient psychotic disorders

目的 探究急性短暂性精神病性障碍(ATPD)患者外周血中非酶类抗氧化物指标的变化。方法 收集150例ATPD患者信息及诊疗记录,最终55例纳入ATPD组、72例纳入非ATPD组,另选取60名年龄、性别、体质量指数(BMI)与之相匹配的志愿者纳入对照组。利用全自动生化仪检测患者急性发病入院时及抗精神病药物治疗2周后血清尿酸(UA)、胆红素(T-BIL)和白蛋白(ALB)水平,采用独立样本t检验或Mann Whitney U检验进行组间比较,分析各组间的水平差异。结果 ATPD组38.18%的患者采用单药治疗,61.81%的患者采用两种药物联合治疗。非ATPD组34.72%的患者采用单药治疗,65.28%的患者采用两种药物联合治疗。ATPD组及非ATPD组治疗前UA水平均高于对照组(P<0.05),但非ATPD组UA水平高于ATPD组(P<0.05);抗精神病药物治疗2周后,ATPD组及非ATPD组UA水平均较治疗前下降(P<0.01),且均低于对照组(P<0.05)。ATPD组及非ATPD组治疗前T-BIL水平均高于对照组(P<0.01);ATPD组及非ATPD组抗精神病药物治疗2周后T-BIL水平均较治疗前降低(P<0.05),但仍高于对照组(P<0.01)。治疗前及抗精神病药物治疗2周后,ATPD组与非ATPD组ALB水平均低于对照组(P<0.05)。结论 氧化应激参与了多种精神异常的急性发作,包括ATPD,此外,抗精神病药物可能具有抗氧化作用。

Objective To explore the changes of non-enzymatic antioxidants in peripheral blood of patients with acute and transient psychotic disorders(ATPD).Methods The general information, diagnosis and treatment records of 150 ATPD patients were collected. Finally, 55 patients in ATPD group, 72 patients in non-ATPD group, and 60 volunteers matched with age, gender and body mass index(BMI) in control group were selected and their serum levels of uric acid(UA), bilirubin(T-BIL) and albumin(ALB) were detected through automatic biochemical analyzer at admission and 2 weeks after antipsychotic treatment. Independent sample t-test or Mann Whitney U test were used to compare the levels between groups. Results In ATPD group, 38.18% of the patients were treated with monotherapy, and 61.81% of the patients were treated with combination therapy. In non-ATPD group, 34.72% of the patients were treated with monotherapy, and 65.28% of the patients were treated with combination therapy. Before treatment, the UA levels in ATPD group and non-ATPD group were higher than that in control group(P<0.05), and the UA level in non-ATPD group was higher than that in ATPD group(P<0.05). After 2 weeks of antipsychotic treatment, UA levels in both ATPD group and non-ATPD group were significantly decreased compared with those before treatment(P<0.01), and were lower than that in control group(P<0.05). The levels of T-BIL in ATPD group and non-ATPD group were higher than that in control group before treatment(P<0.01). After 2 weeks of antipsychotic treatment, the levels of T-BIL in ATPD group and non-ATPD group were all decreased compared with those before treatment(P<0.05), but still higher than that in control group(P<0.01). Before treatment and after 2 weeks of antipsychotic treatment, the levels of ALB in ATPD group and non-ATPD group were all lower than those in control group(P<0.05). Conclusion Oxidative stress is involved in the acute onset of a variety of psychiatric disorders, including ATPD, and in addition, antipsychotics may have antioxidant effects.