血液标志物对阿尔茨海默病诊断价值的再认识

Reconceptualization of the value of blood markers for the diagnosis of Alzheimer disease

阿尔茨海默病(AD)是引起老年性痴呆症最常见的病因,其早期诊断对于延缓病情、改善预后具有十分重要的意义。相较于脑脊液,血液检测具有创伤小且易获取的优势。近年来,随着超敏检测技术的应用,血液标志物对于AD的诊断价值被不断发掘,有望为AD的早期诊断及早期干预提供更加直接有效的证据。

Alzheimer disease(AD)is the most common cause of dementia,and its early diagnosis is of great importance to delay the disease and improve the prognosis.Compared with cerebrospinal fluid,blood tests have the advantages of being less invasive and easier to obtain.In recent years,with the application of ultrasensitive detection technology,the diagnostic value of blood markers for AD has been continuously explored,which is expected to provide more direct and effective evidence for early diagnosis and early intervention of AD.