乙酰氨基酚栓联合磷酸奥司他韦治疗小儿急性上呼吸道感染的效果及对sTRAILR1、sTRAILR4的影响

Effect of Acetaminophen Suppository Combined with Oseltamivir Phosphate on Acute Upper Respiratory Tract Infection in Children and Its Influence on sTRAILR1 and sTRAILR4

目的:探究对乙酰氨基酚栓联合磷酸奥司他韦对小儿急性上呼吸道感染的效果。方法:选取2019年1月-2021年12月于佳木斯市中心医院儿科进行治疗的80例小儿急性上呼吸道感染患者,按照掷硬币法将其分为对照组(n=39)与试验组(n=41)。对照组给予磷酸奥司他韦,试验组在对照组的基础上联合对乙酰氨基酚栓。比较两组临床效果、症状消失时间、不良反应发生情况及肿瘤坏死因子相关凋亡诱导配体(TNF related apoptosis inducing ligand,TRAIL)及其受体(sTRAILR1和sTRAILR4)的蛋白浓度。结果:试验组总有效率高于对照组(P<0.05)。试验组鼻塞流涕、咳嗽、发热、咽喉充血消失时间均短于对照组(P<0.05)。治疗后,试验组TRAIL、sTRAILR1、sTRAILR4浓度均低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对乙酰氨基酚栓联合磷酸奥司他韦治疗小儿急性上呼吸道感染具有效果好、见效快、抗炎能力强等优点,值得临床应用推广。

Objective:To explore the effect of Acetaminophen Suppository combined with Oseltamivir Phosphate on acute upper respiratory tract infection in children.Method:A total of 80 pediatric patients with acute upper respiratory tract infection treated in the Department of Pediatrics of Jiamusi Central Hospital from January 2019 to December 2021 were selected,they were divided into the control group (n=39) and the experimental group (n=41) according to the coin toss method.The control group was given Oseltamivir Phosphate,and the experimental group was given Acetaminophen Suppository on the basis of the control group.The clinical effect,symptom disappearance time,adverse reactions,and TNF related apoptosis inducing ligand (TRAIL) and its receptors (sTRAILR1 and sTRAILR4) were compared between the two groups.Result:The total effective rate of the experimental group was higher than that of the control group (P<0.05).The disappearance time of nasal obstruction and runny nose,cough,fever and throat congestion of the experimental group were shorter than those of the control group (P<0.05).After treatment,the concentrations of TRAIL,sTRAILR1 and sTRAILR4 of the experimental group were lower than those of the control group (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion:Acetaminophen Suppository combined with Oseltamivir Phosphate in the treatment of acute upper respiratory tract infection in children has the advantages of good curative effect,rapid effect,strong anti-inflammatory ability,which is worthy of clinical application and promotion.