间充质干细胞来源外泌体在皮肤损伤修复中的研究进展

Research advances in role of mesenchymal stem cells derived exosomes in wound repair

皮肤损伤是由于疾病或外部暴力而导致的表皮、黏膜或组织破损。间充质干细胞(mesenchymal stem cells,MSCs)修复皮肤损伤已成为一种加速皮肤伤口愈合的选择,其诱导伤口愈合的机制除了直接分化为皮肤常驻细胞外,更依赖于MSC强大的旁分泌作用。外泌体(exosomes,EXOs)作为旁分泌的主要成分,为实现“无细胞治疗”奠定了基础。近年来,外泌体促进组织再生的治疗方法被广泛研究,EXOs促进皮肤愈合的具体机制及其体内应用方法仍在不断完善。本文将对间充质干细胞来源的外泌体在皮肤损伤修复中的机制和应用方法做一综述。

Skin injury is the breakdown of the epidermis,mucous membranes,or tissue due to disease or external violence.Mesenchymal stem cells(MSCs)to repair skin damage have become an option to accelerate skin wound healing.In addition to their differentiation into skin resident cells,the mechanism of wound healing induced by MSCs is mainly contributed to their paracrine effect.As the main component of paracrine,exosomes lay the foundation for the realization of“cell-free therapy”.In recent years,exosome-based tissue regeneration therapeutics are being extensively studied,but the specific mechanisms of exosome in promoting skin healing and methods for in vivo applications are still being refined.This article will review the mechanism and application of mesenchymal stem cell-derived exosomes in skin wound repair.