NLRP3在口腔颌面部放射性组织损伤中的研究进展

Research Progress of NLRP3 in Radiation Injury of Oral and Maxillofacial Tissues

放射治疗是治疗头颈部肿瘤常采用的有效措施之一,而放疗常导致诸如颌面部皮肤、颌骨、口腔黏膜等组织损伤而使其应用受到一定程度的限制,影响患者的预后效果,因此寻找一种有效的防治颌面部放射性损伤的方法是十分必要的。目前已有研究证明NLRP3与放射性损伤疾病有很大的关联,抑制NLRP3的激活可能会有效缓解组织损伤,本文就NLRP3炎症小体结构、激活机制及其放射后在口腔颌面部组织损伤中的作用进行综述。

Radiotherapy is one of the effective measures in the treatment of head and neck tumors. Radiotherapy often leads to tissue damage such as maxillofacial skin, jaw, oral mucosa, and so on, which limits its application to a certain extent and affects the prognosis of patients. Therefore, it is necessary to find an effective method to prevent and treat maxillofacial radiation injuries. At present, studies have proved that NLRP3 is closely related to radiation-induced diseases. Inhibiting the activation mechanism of NLRP3 may effectively alleviate tissue damage. This article reviews the structure and activation mechanism of NLRP3 inflammasome and its role in oral and maxillofacial tissue damage after radiation.