早期奥沙利铂腹腔热灌注化疗在胃癌术后患者中的应用效果

Effect of Early Oxaliplatin Intraperitoneal Thermal Perfusion Chemotherapy on Postoperative Patients with Gastric Cancer

目的研究早期奥沙利铂腹腔热灌注化疗在胃癌术后患者中的应用效果。方法选取2021年1~12月我院收治的接受手术治疗的胃癌患者82例为研究对象,采用随机数表法将患者分为常规组(41例)和联合组(41例)。常规组术后采用常规化疗方案治疗,联合组在常规治疗基础上采用早期奥沙利铂腹腔热灌注化疗治疗。比较两组近期疗效、治疗前、治疗4个周期后卡氏功能状态量表(KPS)评分、血清肿瘤标志物[糖链抗原125(CA125)、糖类抗原199(CA199)、癌胚抗原(CEA)、组织多肽特异性抗原(TPS)]水平、血清重组人DIckkopf相关蛋白1(DKK-1)、人淋巴细胞活化基因3蛋白(LAG-3)水平、不良反应。结果治疗4个周期后,联合组总缓解率87.80%高于常规组68.29%(P<0.05);治疗4个周期后,联合组KPS评分高于常规组(P<0.05);治疗4个周期后,联合组血清CA125、CA199、CEA、TPS水平低于常规组(P<0.05);治疗4个周期后,联合组血清DKK-1、LAG-3水平变化幅度大于常规组(P<0.05);联合组不良反应总发生率为48.78%(20/41),与常规组的36.59%(15/41)比较,差异无统计学意义(P>0.05)。结论早期奥沙利铂腹腔热灌注化疗治疗胃癌术后患者的效果显著,可有效改善患者的功能状态,降低血清肿瘤标志物水平,促进病情恢复。

Objective To study the effect of early oxaliplatin intraperitoneal hyperthermic perfusion chemotherapy in postoperative patients with gastric cancer.Methods A total of 82 patients with gastric cancer who received surgical treatment in our hospital from January 2021 to December 2021 were selected as the research objects.The patients were divided into routine group(41 cases)and combined group(41 cases)by random number table method.The routine group was treated with routine chemotherapy after operation,and the combined group was treated with early oxaliplatin intraperitoneal hyperthermic perfusion chemotherapy on the basis of routine treatment.The short-term efficacy,Karnofsky performance status(KPS)score,serum tumor markers[carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199),carcinoembryonic antigen(CEA),tissue polypeptide specific antigen(TPS)]levels,serum recombinant human Dickkopf associated protein 1(DKK-1),human lymphocyte activation gene 3 protein(LAG-3)levels,and side effects were compared between the two groups.Results After 4 cycles of treatment,the total remission rate in the combined group was 87.80%higher than 68.29%in the conventional group(P<0.05).After 4 cycles of treatment,the KPS score of the combined group was higher than that of the routine group(P<0.05).After 4 cycles of treatment,the levels of serum CA125,CA199,CEA and TPS in the combined group were lower than those in the routine group(P<0.05);After 4 cycles of treatment,the changes of serum DKK-1 and LAG-3 levels of the combined group were greater than those in the routine group(P<0.05).The total incidence of toxic and side effects in the combined group was 48.78%(20/41)compared with 36.59%(15/41)in the conventional group,and the difference was not statistically significant(P>0.05).Conclusion Early oxaliplatin intraperitoneal hyperthermic perfusion chemotherapy is effective in the treatment of postoperative patients with gastric cancer,which can effectively improve the functional status of patients,reduce the level of serum tumor markers,and promote the recovery of the disease.