替吉奥同步放疗治疗老年食管癌的有效性及安全性分析

Efficacy and safety of synchrotron radiotherapy for elderly patients with esophageal cancer

目的:探讨采用替吉奥同步放疗治疗老年食管癌的有效性及安全性。方法:选取南通大学附属肿瘤医院收治的老年食管癌患者62例作为观察对象。按照随机数表法将其分为讨论组(n=31)与常模组(n=31)。常模组患者采用调强放疗技术行外照射治疗,讨论组患者在此基础上行替吉奥化疗。对比两组患者的临床疗效、血清C反应蛋白(CRP)的水平及≥3级中重度不良反应的发生率。结果:讨论组患者治疗的总有效率较常模组患者高,有统计学差异(P<0.05)。治疗后,两组患者血清CRP的水平较治疗前均明显升高,且讨论组患者血清CRP的水平较常模组患者更高,有统计学差异(P<0.05)。治疗后,两组患者≥3级中重度不良反应的发生率相比,无统计学差异(P>0.05)。结论:采用替吉奥同步放疗治疗老年食管癌的疗效较好,能缓解患者的病情,调节CRP的水平,且不会明显增加中重度不良反应,安全性较高。

Objective:To investigate the efficacy and safety of synchronous radiotherapy(SCRT)for elderly patients with esophageal cancer.Methods:Sixty-two elderly patients with esophageal cancer admitted to the Affiliated Cancer Hospital of Nantong University were selected as the observation objects.According to the random number table method,they were divided into discussion group(n=31)and norm group(n=31).Patients in the norm group were treated with intensity-modulated radiotherapy(IMRT),and patients in the discussion group were treated with adjuvant chemotherapy.The clinical efficacy,serum C-reactive protein(CRP)level and the incidence of grade≥3 moderate to severe adverse reactions were compared between the two gr oups.Results:The total effective rate of the discussion group was higher than that of the norm group,and the difference was statistically significant(P<0.05).After treatment,the levels of serum CRP in the two groups were significantly higher than those before treatment,and the level of serum CRP in the discussion group was higher than that in the norm group,with statistical difference(P<0.05).After treatment,there was no significant difference in the incidence of≥3 grade moderate to severe adverse reactions between the two groups(P>0.05).Conclusion:Synchronous radiotherapy for the treatment of elderly esophageal cancer has good efficacy,which can alleviate the disease of patients,regulate the level of CRP,and does not significantly increase moderate to s evere adverse reactions,with high safety.