纤连蛋白冻干粉修护功效的体外研究

Study on repair effect of fibronectin lyophilized powder in vitro

通过体外细胞实验、斑马鱼动物模型实验以及人体修护功效实验等,多维度对新配方制得的纤连蛋白冻干粉的安全性及皮肤修护作用的实际功效进行初步评估。结果显示,研制的纤连蛋白修护冻干粉具有较低的细胞毒性,显著的促细胞迁移、增殖能力及较强皮肤修护功效。纤连蛋白冻干粉具有安全性好、皮肤修护功效强的特点,显示其具有较好的开发前景,研究结果可为修护类护肤品的开发提供新的思路。

Fibronectin has good repair effect on human skin,but its practical application is hindered by easy biodegradation and difficult preservation.Freeze drying technology can prolong the shelf life of biological products,but it may damage some of their biological activities.Therefore,it is necessary to comprehensively and scientifically evaluate the actual efficacy of the fibronectin lyophilized powder prepared by freeze-drying technology.Herein,by means of in vitro cell experiment,zebrafish animal model experiment and human repair efficacy experiment,multi-dimensional detection was used to evaluate the safety of the newly formulated fibronectin lyophilized powder and its actual efficacy of skin repair.The results showed that the fibronectin lyophilized powder had low cytotoxicity,significant abilities to promote cell migration and proliferation,and strong skin repair effect.Therefore,the fibronectin lyophilized powder has the advantages of good safety and strong skin repair efficacy,which provides new ideas for the development of new skin repair cosmetics.