rhIL-2联合冷冻疗法对子宫颈炎合并HPV感染患者免疫功能、氧化应激的影响

Effect of rhIL-2 Combined with Cryotherapy on Immune Function and Oxidative Stress in Patients with Cervicitis Complicated with HPV Infection

目的:分析重组人白细胞介素2(rhIL-2)联合冷冻疗法对子宫颈炎合并HPV感染患者免疫功能、氧化应激的影响。方法:选取2020年1-12月泰和县中医院收治的97例子宫颈炎合并HPV感染患者,使用随机数字表法将其分为对照组(n=48)和观察组(n=49)。对照组给予单纯冷冻疗法治疗,观察组给予rhIL-2联合冷冻疗法治疗。比较两组临床体征评分、HPV-DNA载量、免疫球蛋白(IgA、IgG、IgM)、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]水平及疗效。结果:治疗后,观察组阴道分泌物异常、子宫颈炎症深度、子宫颈炎症面积评分、HPV-DNA载量、MDA水平均低于对照组,HPV转阴率及IgA、IgG、IgM、SOD水平均高于对照组(P<0.05)。观察组总有效率为93.88%,高于对照组的77.08%,差异有统计学意义(P<0.05)。结论:rhIL-2联合冷冻疗法可有效调节子宫颈炎合并HPV感染患者免疫能力水平,减轻氧化应激反应,抑制炎症反应,优化临床疗效。

Objective:To analyze the effects of recombinant human interleukin-2(rhIL-2)combined with cryotherapy on immune function and oxidative stress in patients with cervicitis complicated with HPV infection.Method:A total of 97 patients with cervicitis complicated with HPV infection admitted to Taihe Hospital of Traditional Chinese Medicine from January to December 2020 were selected,they were divided into control group(n=48)and observation group(n=49)according to random number table method.The control group was treated with cryotherapy alone,while the observation group was treated with rhIL-2 combined with cryotherapy.The clinical sign scores,HPV-DNA load,immunoglobulin(IgA,IgG,IgM),oxidative stress index[superoxide dismutase(SOD),malondialdehyde(MDA)]and efficacy were compared between the two groups.Result:After treatment,the vaginal discharge was abnormal,cervical inflammation depth,cervical inflammation area score,HPV-DNA load and MDA level were lower than the control group,and the HPV negative turn rate and IgA,IgG,IgM and SOD levels were higher than the control group(P<0.05).The total response rate of the observation group was 93.88%,which was higher than the 77.08%of the control group,and the difference was statistically significant(P<0.05).Conclusion:rhIL-2 combined with cryotherapy can effectively regulate the level of immune ability in patients with cervicitis complicated with HPV infection,reduce oxidative stress response,inhibit inflammatory response and optimize clinical efficacy.