mNGF穴位注射辅助治疗对脑瘫痉挛型双瘫患儿GMFM评分、Lac及TNF-α水平的影响

Effects of acupoint injection adjuvant therapy of mNGF on GMFM score, Lac and TNF-α levels in children with spastic diplegia of cerebral palsy

目的研究鼠神经生长因子(mNGF)穴位注射辅助治疗对脑瘫痉挛型双瘫患儿粗大运动功能及血清乳酸(Lac)、肿瘤坏死因子-α(TNF-α)水平的影响。方法收集2018年2月~2020年10月于我院治疗的107例脑瘫痉挛型双瘫患儿的临床资料,根据治疗方式不同分为对照组(53例)和观察组(54例),对照组给予常规康复训练治疗,观察组在其基础上给予mNGF穴位注射辅助治疗。对比两组临床疗效、粗大运动功能评分(GMFM)、日常生活活动能力评分(ADL)、不良反应发生情况及血清Lac、TNF-α水平。结果①观察组总有效率96.30%高于对照组(83.02%),差异有统计学意义(P<0.05)。②治疗后两组GMFM评分、ADL评分均呈上升趋势,且治疗后2个月及治疗后3个月观察组GMFM评分高于对照组,差异均有统计学意义(P<0.05)。③治疗后两组TNF-α、Lac水平均下降,且以观察组下降更为明显,差异均有统计学意义(P<0.05)。④两组不良反应发生率无明显差异。结论mNGF穴位注射辅助治疗脑瘫痉挛型双瘫患儿临床疗效显著,提高了患儿的运动能力及生活能力,具有一定安全性。

Objective To study the effects of acupoint injection adjuvant therapy of mouse nerve growth factor(mNGF)on the gross motor function,blood lactic acid(Lac)and tumor necrosis factor-α(TNF-α)levels in children with spastic diplegia of cerebral palsy. Methods The clinical data of 107 children with spastic diplegia of cerebral palsy treated in our hospital from February 2018 to October 2020 were collected,according to different treatment methods,they were divided into the control group(53 cases)and the observation group(54 cases),the control group was given routine rehabilitation training,and the observation group was given mNGF acupoint injection adjuvant therapy on this basis of the control group.The clinical efficacy,gross motor function measure(GMFM),Activity of Daily Living(ADL),the occurrence of adverse reactions,serum Lac and TNF-αlevels between the two groups were compared. Results ①The total curative effect of the observation group 96.30%was higher than that of the control group(83.02%),and the difference was statistically significant(P<0.05).②The GMFM score and ADL score of the two groups showed an upward trend after treatment,and the GMFM scores of the observation group were higher than those of the control group 2 months after treatment and 3 months after treatment(P<0.05).③The levels of TNF-αand Lac in the two groups decreased after treatment,and the decreasing was more obvious in the observation group(P<0.05).④The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05). Conclusion The adjuvant treatment of mNGF acupoint injection in children with spastic diplegia of cerebral palsy has a significant clinical efficacy,which can improve the children's athletic ability and living ability,and has safety to some extent.